Identification of Hemorrhage and Infarct Lesions on Brain CT Images using Deep Learning

Head Non-contrast computed tomography (NCCT) scan remain the preferred primary imaging modality due to their widespread availability and speed. However, the current standard for manual annotations of abnormal brain tissue on head NCCT scans involves significant disadvantages like lack of cutoff standardization and degeneration identification. The recent advancement of deep learning-based computer-aided diagnostic (CAD) models in the multidisciplinary domain has created vast opportunities in neurological medical imaging. Significant literature has been published earlier in the automated identification of brain tissue on different imaging modalities. However, determining Intracranial hemorrhage (ICH) and infarct can be challenging due to image texture, volume size, and scan quality variability. This retrospective validation study evaluated a DL-based algorithm identifying ICH and infarct from head-NCCT scans. The head-NCCT scans dataset was collected consecutively from multiple diagnostic imaging centers across India. The study exhibits the potential and limitations of such DL-based software for introduction in routine workflow in extensive healthcare facilities.

Deep-ASPECTS: A Segmentation-Assisted Model for Stroke Severity Measurement

A stroke occurs when an artery in the brain ruptures and bleeds or when the blood supply to the brain is cut off. Blood and oxygen cannot reach the brain's tissues due to the rupture or obstruction resulting in tissue death. The Middle cerebral artery (MCA) is the largest cerebral artery and the most commonly damaged vessel in stroke. The quick onset of a focused neurological deficit caused by interruption of blood flow in the territory supplied by the MCA is known as an MCA stroke. Alberta stroke programme early CT score (ASPECTS) is used to estimate the extent of early ischemic changes in patients with MCA stroke. This study proposes a deep learning-based method to score the CT scan for ASPECTS. Our work has three highlights. First, we propose a novel method for medical image segmentation for stroke detection. Second, we show the effectiveness of AI solution for fully-automated ASPECT scoring with reduced diagnosis time for a given non-contrast CT (NCCT) Scan. Our algorithms show a dice similarity coefficient of 0.64 for the MCA anatomy segmentation and 0.72 for the infarcts segmentation. Lastly, we show that our model's performance is inline with inter-reader variability between radiologists.

Generating Out of Distribution Adversarial Attack using Latent Space Poisoning

Traditional adversarial attacks rely upon the perturbations generated by gradients from the network which are generally safeguarded by gradient guided search to provide an adversarial counterpart to the network. In this paper, we propose a novel mechanism of generating adversarial examples where the actual image is not corrupted rather its latent space representation is utilized to tamper with the inherent structure of the image while maintaining the perceptual quality intact and to act as legitimate data samples. As opposed to gradient-based attacks, the latent space poisoning exploits the inclination of classifiers to model the independent and identical distribution of the training dataset and tricks it by producing out of distribution samples. We train a disentangled variational autoencoder (beta-VAE) to model the data in latent space and then we add noise perturbations using a class-conditioned distribution function to the latent space under the constraint that it is misclassified to the target label. Our empirical results on MNIST, SVHN, and CelebA dataset validate that the generated adversarial examples can easily fool robust l_0, l_2, l_inf norm classifiers designed using provably robust defense mechanisms.