GLip: A Global-Local Integrated Progressive Framework for Robust Visual Speech Recognition

Visual speech recognition (VSR), also known as lip reading, is the task of recognizing speech from silent video. Despite significant advancements in VSR over recent decades, most existing methods pay limited attention to real-world visual challenges such as illumination variations, occlusions, blurring, and pose changes. To address these challenges, we propose GLip, a Global-Local Integrated Progressive framework designed for robust VSR. GLip is built upon two key insights: (i) learning an initial \textit{coarse} alignment between visual features across varying conditions and corresponding speech content facilitates the subsequent learning of \textit{precise} visual-to-speech mappings in challenging environments; (ii) under adverse conditions, certain local regions (e.g., non-occluded areas) often exhibit more discriminative cues for lip reading than global features. To this end, GLip introduces a dual-path feature extraction architecture that integrates both global and local features within a two-stage progressive learning framework. In the first stage, the model learns to align both global and local visual features with corresponding acoustic speech units using easily accessible audio-visual data, establishing a coarse yet semantically robust foundation. In the second stage, we introduce a Contextual Enhancement Module (CEM) to dynamically integrate local features with relevant global context across both spatial and temporal dimensions, refining the coarse representations into precise visual-speech mappings. Our framework uniquely exploits discriminative local regions through a progressive learning strategy, demonstrating enhanced robustness against various visual challenges and consistently outperforming existing methods on the LRS2 and LRS3 benchmarks. We further validate its effectiveness on a newly introduced challenging Mandarin dataset.

Collaborative Expert LLMs Guided Multi-Objective Molecular Optimization

Molecular optimization is a crucial yet complex and time-intensive process that often acts as a bottleneck for drug development. Traditional methods rely heavily on trial and error, making multi-objective optimization both time-consuming and resource-intensive. Current AI-based methods have shown limited success in handling multi-objective optimization tasks, hampering their practical utilization. To address this challenge, we present MultiMol, a collaborative large language model (LLM) system designed to guide multi-objective molecular optimization. MultiMol comprises two agents, including a data-driven worker agent and a literature-guided research agent. The data-driven worker agent is a large language model being fine-tuned to learn how to generate optimized molecules considering multiple objectives, while the literature-guided research agent is responsible for searching task-related literature to find useful prior knowledge that facilitates identifying the most promising optimized candidates. In evaluations across six multi-objective optimization tasks, MultiMol significantly outperforms existing methods, achieving a 82.30% success rate, in sharp contrast to the 27.50% success rate of current strongest methods. To further validate its practical impact, we tested MultiMol on two real-world challenges. First, we enhanced the selectivity of Xanthine Amine Congener (XAC), a promiscuous ligand that binds both A1R and A2AR, successfully biasing it towards A1R. Second, we improved the bioavailability of Saquinavir, an HIV-1 protease inhibitor with known bioavailability limitations. Overall, these results indicate that MultiMol represents a highly promising approach for multi-objective molecular optimization, holding great potential to accelerate the drug development process and contribute to the advancement of pharmaceutical research.