Fully Convolutional Model for Variable Bit Length and Lossy High Density Compression of Mammograms

Early works on medical image compression date to the 1980's with the impetus on deployment of teleradiology systems for high-resolution digital X-ray detectors. Commercially deployed systems during the period could compress 4,096 x 4,096 sized images at 12 bpp to 2 bpp using lossless arithmetic coding, and over the years JPEG and JPEG2000 were imbibed reaching upto 0.1 bpp. Inspired by the reprise of deep learning based compression for natural images over the last two years, we propose a fully convolutional autoencoder for diagnostically relevant feature preserving lossy compression. This is followed by leveraging arithmetic coding for encapsulating high redundancy of features for further high-density code packing leading to variable bit length. We demonstrate performance on two different publicly available digital mammography datasets using peak signal-to-noise ratio (pSNR), structural similarity (SSIM) index and domain adaptability tests between datasets. At high density compression factors of >300x (~0.04 bpp), our approach rivals JPEG and JPEG2000 as evaluated through a Radiologist's visual Turing test.

ReLayNet: Retinal Layer and Fluid Segmentation of Macular Optical Coherence Tomography using Fully Convolutional Network

Optical coherence tomography (OCT) is used for non-invasive diagnosis of diabetic macular edema assessing the retinal layers. In this paper, we propose a new fully convolutional deep architecture, termed ReLayNet, for end-to-end segmentation of retinal layers and fluid masses in eye OCT scans. ReLayNet uses a contracting path of convolutional blocks (encoders) to learn a hierarchy of contextual features, followed by an expansive path of convolutional blocks (decoders) for semantic segmentation. ReLayNet is trained to optimize a joint loss function comprising of weighted logistic regression and Dice overlap loss. The framework is validated on a publicly available benchmark dataset with comparisons against five state-of-the-art segmentation methods including two deep learning based approaches to substantiate its effectiveness.