PathoSCOPE: Few-Shot Pathology Detection via Self-Supervised Contrastive Learning and Pathology-Informed Synthetic Embeddings

Unsupervised pathology detection trains models on non-pathological data to flag deviations as pathologies, offering strong generalizability for identifying novel diseases and avoiding costly annotations. However, building reliable normality models requires vast healthy datasets, as hospitals' data is inherently biased toward symptomatic populations, while privacy regulations hinder the assembly of representative healthy cohorts. To address this limitation, we propose PathoSCOPE, a few-shot unsupervised pathology detection framework that requires only a small set of non-pathological samples (minimum 2 shots), significantly improving data efficiency. We introduce Global-Local Contrastive Loss (GLCL), comprised of a Local Contrastive Loss to reduce the variability of non-pathological embeddings and a Global Contrastive Loss to enhance the discrimination of pathological regions. We also propose a Pathology-informed Embedding Generation (PiEG) module that synthesizes pathological embeddings guided by the global loss, better exploiting the limited non-pathological samples. Evaluated on the BraTS2020 and ChestXray8 datasets, PathoSCOPE achieves state-of-the-art performance among unsupervised methods while maintaining computational efficiency (2.48 GFLOPs, 166 FPS).

VISTA: Unsupervised 2D Temporal Dependency Representations for Time Series Anomaly Detection

Time Series Anomaly Detection (TSAD) is essential for uncovering rare and potentially harmful events in unlabeled time series data. Existing methods are highly dependent on clean, high-quality inputs, making them susceptible to noise and real-world imperfections. Additionally, intricate temporal relationships in time series data are often inadequately captured in traditional 1D representations, leading to suboptimal modeling of dependencies. We introduce VISTA, a training-free, unsupervised TSAD algorithm designed to overcome these challenges. VISTA features three core modules: 1) Time Series Decomposition using Seasonal and Trend Decomposition via Loess (STL) to decompose noisy time series into trend, seasonal, and residual components; 2) Temporal Self-Attention, which transforms 1D time series into 2D temporal correlation matrices for richer dependency modeling and anomaly detection; and 3) Multivariate Temporal Aggregation, which uses a pretrained feature extractor to integrate cross-variable information into a unified, memory-efficient representation. VISTA's training-free approach enables rapid deployment and easy hyperparameter tuning, making it suitable for industrial applications. It achieves state-of-the-art performance on five multivariate TSAD benchmarks.