Is SAM3 ready for pathology segmentation?

Is Segment Anything Model 3 (SAM3) capable in segmenting Any Pathology Images? Digital pathology segmentation spans tissue-level and nuclei-level scales, where traditional methods often suffer from high annotation costs and poor generalization. SAM3 introduces Promptable Concept Segmentation, offering a potential automated interface via text prompts. With this work, we propose a systematic evaluation protocol to explore the capability space of SAM3 in a structured manner. Specifically, we evaluate SAM3 under different supervision settings including zero-shot, few-shot, and supervised with varying prompting strategies. Our extensive evaluation on pathological datasets including NuInsSeg, PanNuke and GlaS, reveals that: 1.text-only prompts poorly activate nuclear concepts. 2.performance is highly sensitive to visual prompt types and budgets. 3.few-shot learning offers gains, but SAM3 lacks robustness against visual prompt noise. and 4.a significant gap persists between prompt-based usage and task-trained adapter-based reference. Our study delineates SAM3's boundaries in pathology image segmentation and provides practical guidance on the necessity of pathology domain adaptation.

Robust Anomaly Detection in Industrial Environments via Meta-Learning

Anomaly detection is fundamental for ensuring quality control and operational efficiency in industrial environments, yet conventional approaches face significant challenges when training data contains mislabeled samples-a common occurrence in real-world scenarios. This paper presents RAD, a robust anomaly detection framework that integrates Normalizing Flows with Model-Agnostic Meta-Learning to address the critical challenge of label noise in industrial settings. Our approach employs a bi-level optimization strategy where meta-learning enables rapid adaptation to varying noise conditions, while uncertainty quantification guides adaptive L2 regularization to maintain model stability. The framework incorporates multiscale feature processing through pretrained feature extractors and leverages the precise likelihood estimation capabilities of Normalizing Flows for robust anomaly scoring. Comprehensive evaluation on MVTec-AD and KSDD2 datasets demonstrates superior performance, achieving I-AUROC scores of 95.4% and 94.6% respectively under clean conditions, while maintaining robust detection capabilities above 86.8% and 92.1% even when 50% of training samples are mislabeled. The results highlight RAD's exceptional resilience to noisy training conditions and its ability to detect subtle anomalies across diverse industrial scenarios, making it a practical solution for real-world anomaly detection applications where perfect data curation is challenging.

Meta Learning-Driven Iterative Refinement for Robust Anomaly Detection in Industrial Inspection

This study investigates the performance of robust anomaly detection models in industrial inspection, focusing particularly on their ability to handle noisy data. We propose to leverage the adaptation ability of meta learning approaches to identify and reject noisy training data to improve the learning process. In our model, we employ Model Agnostic Meta Learning (MAML) and an iterative refinement process through an Inter-Quartile Range rejection scheme to enhance their adaptability and robustness. This approach significantly improves the models capability to distinguish between normal and defective conditions. Our results of experiments conducted on well known MVTec and KSDD2 datasets demonstrate that the proposed method not only excels in environments with substantial noise but can also contribute in case of a clear training set, isolating those samples that are relatively out of distribution, thus offering significant improvements over traditional models.

Self-Supervised Iterative Refinement for Anomaly Detection in Industrial Quality Control

This study introduces the Iterative Refinement Process (IRP), a robust anomaly detection methodology designed for high-stakes industrial quality control. The IRP enhances defect detection accuracy through a cyclic data refinement strategy, iteratively removing misleading data points to improve model performance and robustness. We validate the IRP's effectiveness using two benchmark datasets, Kolektor SDD2 (KSDD2) and MVTec AD, covering a wide range of industrial products and defect types. Our experimental results demonstrate that the IRP consistently outperforms traditional anomaly detection models, particularly in environments with high noise levels. This study highlights the IRP's potential to significantly enhance anomaly detection processes in industrial settings, effectively managing the challenges of sparse and noisy data.