A Systematic Benchmarking Analysis of Transfer Learning for Medical Image Analysis

Transfer learning from supervised ImageNet models has been frequently used in medical image analysis. Yet, no large-scale evaluation has been conducted to benchmark the efficacy of newly-developed pre-training techniques for medical image analysis, leaving several important questions unanswered. As the first step in this direction, we conduct a systematic study on the transferability of models pre-trained on iNat2021, the most recent large-scale fine-grained dataset, and 14 top self-supervised ImageNet models on 7 diverse medical tasks in comparison with the supervised ImageNet model. Furthermore, we present a practical approach to bridge the domain gap between natural and medical images by continually (pre-)training supervised ImageNet models on medical images. Our comprehensive evaluation yields new insights: (1) pre-trained models on fine-grained data yield distinctive local representations that are more suitable for medical segmentation tasks, (2) self-supervised ImageNet models learn holistic features more effectively than supervised ImageNet models, and (3) continual pre-training can bridge the domain gap between natural and medical images. We hope that this large-scale open evaluation of transfer learning can direct the future research of deep learning for medical imaging. As open science, all codes and pre-trained models are available on our GitHub page https://github.com/JLiangLab/BenchmarkTransferLearning.

Learning Fixed Points in Generative Adversarial Networks: From Image-to-Image Translation to Disease Detection and Localization

Generative adversarial networks (GANs) have ushered in a revolution in image-to-image translation. The development and proliferation of GANs raises an interesting question: can we train a GAN to remove an object, if present, from an image while otherwise preserving the image? Specifically, can a GAN "virtually heal" anyone by turning his medical image, with an unknown health status (diseased or healthy), into a healthy one, so that diseased regions could be revealed by subtracting those two images? Such a task requires a GAN to identify a minimal subset of target pixels for domain translation, an ability that we call fixed-point translation, which no GAN is equipped with yet. Therefore, we propose a new GAN, called Fixed-Point GAN, trained by (1) supervising same-domain translation through a conditional identity loss, and (2) regularizing cross-domain translation through revised adversarial, domain classification, and cycle consistency loss. Based on fixed-point translation, we further derive a novel framework for disease detection and localization using only image-level annotation. Qualitative and quantitative evaluations demonstrate that the proposed method outperforms the state of the art in multi-domain image-to-image translation and that it surpasses predominant weakly-supervised localization methods in both disease detection and localization. Implementation is available at https://github.com/jlianglab/Fixed-Point-GAN.

Models Genesis: Generic Autodidactic Models for 3D Medical Image Analysis

Transfer learning from natural image to medical image has established as one of the most practical paradigms in deep learning for medical image analysis. However, to fit this paradigm, 3D imaging tasks in the most prominent imaging modalities (e.g., CT and MRI) have to be reformulated and solved in 2D, losing rich 3D anatomical information and inevitably compromising the performance. To overcome this limitation, we have built a set of models, called Generic Autodidactic Models, nicknamed Models Genesis, because they are created ex nihilo (with no manual labeling), self-taught (learned by self-supervision), and generic (served as source models for generating application-specific target models). Our extensive experiments demonstrate that our Models Genesis significantly outperform learning from scratch in all five target 3D applications covering both segmentation and classification. More importantly, learning a model from scratch simply in 3D may not necessarily yield performance better than transfer learning from ImageNet in 2D, but our Models Genesis consistently top any 2D approaches including fine-tuning the models pre-trained from ImageNet as well as fine-tuning the 2D versions of our Models Genesis, confirming the importance of 3D anatomical information and significance of our Models Genesis for 3D medical imaging. This performance is attributed to our unified self-supervised learning framework, built on a simple yet powerful observation: the sophisticated yet recurrent anatomy in medical images can serve as strong supervision signals for deep models to learn common anatomical representation automatically via self-supervision. As open science, all pre-trained Models Genesis are available at https://github.com/MrGiovanni/ModelsGenesis.

l0-norm Based Centers Selection for Training Fault Tolerant RBF Networks and Selecting Centers

The aim of this paper is to train an RBF neural network and select centers under concurrent faults. It is well known that fault tolerance is a very attractive property for neural networks. And center selection is an important procedure during the training process of an RBF neural network. In this paper, we devise two novel algorithms to address these two issues simultaneously. Both of them are based on the ADMM framework. In the first method, the minimax concave penalty (MCP) function is introduced to select centers. In the second method, an l0-norm term is directly used, and the hard threshold (HT) is utilized to address the l0-norm term. Under several mild conditions, we can prove that both methods can globally converge to a unique limit point. Simulation results show that, under concurrent fault, the proposed algorithms are superior to many existing methods.

Fast L1-Minimization Algorithm for Sparse Approximation Based on an Improved LPNN-LCA framework

The aim of sparse approximation is to estimate a sparse signal according to the measurement matrix and an observation vector. It is widely used in data analytics, image processing, and communication, etc. Up to now, a lot of research has been done in this area, and many off-the-shelf algorithms have been proposed. However, most of them cannot offer a real-time solution. To some extent, this shortcoming limits its application prospects. To address this issue, we devise a novel sparse approximation algorithm based on Lagrange programming neural network (LPNN), locally competitive algorithm (LCA), and projection theorem. LPNN and LCA are both analog neural network which can help us get a real-time solution. The non-differentiable objective function can be solved by the concept of LCA. Utilizing the projection theorem, we further modify the dynamics and proposed a new system with global asymptotic stability. Simulation results show that the proposed sparse approximation method has the real-time solutions with satisfactory MSEs.