ODySSeI: An Open-Source End-to-End Framework for Automated Detection, Segmentation, and Severity Estimation of Lesions in Invasive Coronary Angiography Images

Invasive Coronary Angiography (ICA) is the clinical gold standard for the assessment of coronary artery disease. However, its interpretation remains subjective and prone to intra- and inter-operator variability. In this work, we introduce ODySSeI: an Open-source end-to-end framework for automated Detection, Segmentation, and Severity estimation of lesions in ICA images. ODySSeI integrates deep learning-based lesion detection and lesion segmentation models trained using a novel Pyramidal Augmentation Scheme (PAS) to enhance robustness and real-time performance across diverse patient cohorts (2149 patients from Europe, North America, and Asia). Furthermore, we propose a quantitative coronary angiography-free Lesion Severity Estimation (LSE) technique that directly computes the Minimum Lumen Diameter (MLD) and diameter stenosis from the predicted lesion geometry. Extensive evaluation on both in-distribution and out-of-distribution clinical datasets demonstrates ODySSeI's strong generalizability. Our PAS yields large performance gains in highly complex tasks as compared to relatively simpler ones, notably, a 2.5-fold increase in lesion detection performance versus a 1-3\% increase in lesion segmentation performance over their respective baselines. Our LSE technique achieves high accuracy, with predicted MLD values differing by only $\pm$ 2-3 pixels from the corresponding ground truths. On average, ODySSeI processes a raw ICA image within only a few seconds on a CPU and in a fraction of a second on a GPU and is available as a plug-and-play web interface at swisscardia.epfl.ch. Overall, this work establishes ODySSeI as a comprehensive and open-source framework which supports automated, reproducible, and scalable ICA analysis for real-time clinical decision-making.

Position: Message-passing and spectral GNNs are two sides of the same coin

Graph neural networks (GNNs) are commonly divided into message-passing neural networks (MPNNs) and spectral graph neural networks, reflecting two largely separate research traditions in machine learning and signal processing. This paper argues that this divide is mostly artificial, hindering progress in the field. We propose a viewpoint in which both MPNNs and spectral GNNs are understood as different parametrizations of permutation-equivariant operators acting on graph signals. From this perspective, many popular architectures are equivalent in expressive power, while genuine gaps arise only in specific regimes. We further argue that MPNNs and spectral GNNs offer complementary strengths. That is, MPNNs provide a natural language for discrete structure and expressivity analysis using tools from logic and graph isomorphism research, while the spectral perspective provides principled tools for understanding smoothing, bottlenecks, stability, and community structure. Overall, we posit that progress in graph learning will be accelerated by clearly understanding the key similarities and differences between these two types of GNNs, and by working towards unifying these perspectives within a common theoretical and conceptual framework rather than treating them as competing paradigms.

Model soups need only one ingredient

Fine-tuning large pre-trained models on a target distribution often improves in-distribution (ID) accuracy, but at the cost of out-of-distribution (OOD) robustness as representations specialize to the fine-tuning data. Weight-space ensembling methods, such as Model Soups, mitigate this effect by averaging multiple checkpoints, but they are computationally prohibitive, requiring the training and storage of dozens of fine-tuned models. In this paper, we introduce MonoSoup, a simple, data-free, hyperparameter-free, post-hoc method that achieves a strong ID-OOD balance using only a single checkpoint. Our method applies Singular Value Decomposition (SVD) to each layer's update and decomposes it into high-energy directions that capture task-specific adaptation and low-energy directions that introduce noise but may still encode residual signals useful for robustness. MonoSoup then uses entropy-based effective rank to automatically re-weigh these components with layer-wise coefficients that account for the spectral and geometric structure of the model. Experiments on CLIP models fine-tuned on ImageNet and evaluated under natural distribution shifts, as well as on Qwen language models tested on mathematical reasoning and multiple-choice benchmarks, show that this plug-and-play approach is a practical and effective alternative to multi-checkpoint methods, retaining much of their benefits without their computational overhead.

Task Addition and Weight Disentanglement in Closed-Vocabulary Models

Task arithmetic has recently emerged as a promising method for editing pre-trained \textit{open-vocabulary} models, offering a cost-effective alternative to standard multi-task fine-tuning. However, despite the abundance of \textit{closed-vocabulary} models that are not pre-trained with language supervision, applying task arithmetic to these models remains unexplored. In this paper, we deploy and study task addition in closed-vocabulary image classification models. We consider different pre-training schemes and find that \textit{weight disentanglement} -- the property enabling task arithmetic -- is a general consequence of pre-training, as it appears in different pre-trained closed-vocabulary models. In fact, we find that pre-trained closed-vocabulary vision transformers can also be edited with task arithmetic, achieving high task addition performance and enabling the efficient deployment of multi-task models. Finally, we demonstrate that simple linear probing is a competitive baseline to task addition. Overall, our findings expand the applicability of task arithmetic to a broader class of pre-trained models and open the way for more efficient use of pre-trained models in diverse settings.

Semantic Document Derendering: SVG Reconstruction via Vision-Language Modeling

Multimedia documents such as slide presentations and posters are designed to be interactive and easy to modify. Yet, they are often distributed in a static raster format, which limits editing and customization. Restoring their editability requires converting these raster images back into structured vector formats. However, existing geometric raster-vectorization methods, which rely on low-level primitives like curves and polygons, fall short at this task. Specifically, when applied to complex documents like slides, they fail to preserve the high-level structure, resulting in a flat collection of shapes where the semantic distinction between image and text elements is lost. To overcome this limitation, we address the problem of semantic document derendering by introducing SliDer, a novel framework that uses Vision-Language Models (VLMs) to derender slide images as compact and editable Scalable Vector Graphic (SVG) representations. SliDer detects and extracts attributes from individual image and text elements in a raster input and organizes them into a coherent SVG format. Crucially, the model iteratively refines its predictions during inference in a process analogous to human design, generating SVG code that more faithfully reconstructs the original raster upon rendering. Furthermore, we introduce Slide2SVG, a novel dataset comprising raster-SVG pairs of slide documents curated from real-world scientific presentations, to facilitate future research in this domain. Our results demonstrate that SliDer achieves a reconstruction LPIPS of 0.069 and is favored by human evaluators in 82.9% of cases compared to the strongest zero-shot VLM baseline.

rETF-semiSL: Semi-Supervised Learning for Neural Collapse in Temporal Data

Deep neural networks for time series must capture complex temporal patterns, to effectively represent dynamic data. Self- and semi-supervised learning methods show promising results in pre-training large models, which -- when finetuned for classification -- often outperform their counterparts trained from scratch. Still, the choice of pretext training tasks is often heuristic and their transferability to downstream classification is not granted, thus we propose a novel semi-supervised pre-training strategy to enforce latent representations that satisfy the Neural Collapse phenomenon observed in optimally trained neural classifiers. We use a rotational equiangular tight frame-classifier and pseudo-labeling to pre-train deep encoders with few labeled samples. Furthermore, to effectively capture temporal dynamics while enforcing embedding separability, we integrate generative pretext tasks with our method, and we define a novel sequential augmentation strategy. We show that our method significantly outperforms previous pretext tasks when applied to LSTMs, transformers, and state-space models on three multivariate time series classification datasets. These results highlight the benefit of aligning pre-training objectives with theoretically grounded embedding geometry.

CM-UNet: A Self-Supervised Learning-Based Model for Coronary Artery Segmentation in X-Ray Angiography

Accurate segmentation of coronary arteries remains a significant challenge in clinical practice, hindering the ability to effectively diagnose and manage coronary artery disease. The lack of large, annotated datasets for model training exacerbates this issue, limiting the development of automated tools that could assist radiologists. To address this, we introduce CM-UNet, which leverages self-supervised pre-training on unannotated datasets and transfer learning on limited annotated data, enabling accurate disease detection while minimizing the need for extensive manual annotations. Fine-tuning CM-UNet with only 18 annotated images instead of 500 resulted in a 15.2% decrease in Dice score, compared to a 46.5% drop in baseline models without pre-training. This demonstrates that self-supervised learning can enhance segmentation performance and reduce dependence on large datasets. This is one of the first studies to highlight the importance of self-supervised learning in improving coronary artery segmentation from X-ray angiography, with potential implications for advancing diagnostic accuracy in clinical practice. By enhancing segmentation accuracy in X-ray angiography images, the proposed approach aims to improve clinical workflows, reduce radiologists' workload, and accelerate disease detection, ultimately contributing to better patient outcomes. The source code is publicly available at https://github.com/CamilleChallier/Contrastive-Masked-UNet.

MEMOIR: Lifelong Model Editing with Minimal Overwrite and Informed Retention for LLMs

Language models deployed in real-world systems often require post-hoc updates to incorporate new or corrected knowledge. However, editing such models efficiently and reliably - without retraining or forgetting previous information - remains a major challenge. Existing methods for lifelong model editing either compromise generalization, interfere with past edits, or fail to scale to long editing sequences. We propose MEMOIR, a novel scalable framework that injects knowledge through a residual memory, i.e., a dedicated parameter module, while preserving the core capabilities of the pre-trained model. By sparsifying input activations through sample-dependent masks, MEMOIR confines each edit to a distinct subset of the memory parameters, minimizing interference among edits. At inference, it identifies relevant edits by comparing the sparse activation patterns of new queries to those stored during editing. This enables generalization to rephrased queries by activating only the relevant knowledge while suppressing unnecessary memory activation for unrelated prompts. Experiments on question answering, hallucination correction, and out-of-distribution generalization benchmarks across LLaMA-3 and Mistral demonstrate that MEMOIR achieves state-of-the-art performance across reliability, generalization, and locality metrics, scaling to thousands of sequential edits with minimal forgetting.

Single-Input Multi-Output Model Merging: Leveraging Foundation Models for Dense Multi-Task Learning

Model merging is a flexible and computationally tractable approach to merge single-task checkpoints into a multi-task model. Prior work has solely focused on constrained multi-task settings where there is a one-to-one mapping between a sample and a task, overlooking the paradigm where multiple tasks may operate on the same sample, e.g., scene understanding. In this paper, we focus on the multi-task setting with single-input-multiple-outputs (SIMO) and show that it qualitatively differs from the single-input-single-output model merging settings studied in the literature due to the existence of task-specific decoders and diverse loss objectives. We identify that existing model merging methods lead to significant performance degradation, primarily due to representation misalignment between the merged encoder and task-specific decoders. We propose two simple and efficient fixes for the SIMO setting to re-align the feature representation after merging. Compared to joint fine-tuning, our approach is computationally effective and flexible, and sheds light into identifying task relationships in an offline manner. Experiments on NYUv2, Cityscapes, and a subset of the Taskonomy dataset demonstrate: (1) task arithmetic suffices to enable multi-task capabilities; however, the representations generated by the merged encoder has to be re-aligned with the task-specific heads; (2) the proposed architecture rivals traditional multi-task learning in performance but requires fewer samples and training steps by leveraging the existence of task-specific models.

Revisiting Automatic Data Curation for Vision Foundation Models in Digital Pathology

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly heterogeneous tiles extracted from whole-slide images (WSIs) of real-world patient samples. The performance of these FMs is significantly influenced by the size, diversity, and balance of the pre-training data. However, data selection has been primarily guided by expert knowledge at the WSI level, focusing on factors such as disease classification and tissue types, while largely overlooking the granular details available at the tile level. In this paper, we investigate the potential of unsupervised automatic data curation at the tile-level, taking into account 350 million tiles. Specifically, we apply hierarchical clustering trees to pre-extracted tile embeddings, allowing us to sample balanced datasets uniformly across the embedding space of the pretrained FM. We further identify these datasets are subject to a trade-off between size and balance, potentially compromising the quality of representations learned by FMs, and propose tailored batch sampling strategies to mitigate this effect. We demonstrate the effectiveness of our method through improved performance on a diverse range of clinically relevant downstream tasks.