Continuous Blood Monitoring with Particle-based Integrated Sensing and Communication (ISAC)

Although the circulatory system functions as a continuous source of physiological data, contemporary diagnostics remain bound to intermittent, time-delayed assessments. To resolve this, we present a framework for ubiquitous hematological profiling driven by Integrated Sensing and Communication (ISAC). We demonstrate how electromagnetic signals can be exploited to monitor blood in real-time, effectively converting them into diagnostic tools. We analyze the biological foundations of blood, review existing Complete Blood Count (CBC) and sensing technologies, and detail a novel pipeline for continuous blood monitoring. Furthermore, we discuss the potential applications of deploying these devices to enable real-time CBC and biomarker detection, ultimately revolutionizing how we predict, detect, and manage individual and public health.

Odor Communication with Green Leaf Volatiles for Stress Signalling in the Internet of Plants

This paper develops an end-to-end odor communication model for stress signaling between plants using Green Leaf Volatiles (GLV). A damaged transmitter plant emits (Z)-3-hexenal, (Z)-3-hexenol, and (Z)-3-hexenyl acetate, which propagate through a time-varying diffusion-advection channel and undergo multiplicative loss at the receiver. The sink plant is modeled with a biochemical receiver network that converts the received GLVs into the defensive metabolite (Z)-3-hexenyl $β$-vicianoside, and an alarm decision is defined based on its concentration level. Numerical results show that (Z)-3-hexenol is the primary driver of the system and that plant perception generally operates in a non-linear region. These findings provide a framework for understanding the evolution of plant-plant communication and for developing next-generation precision farming technologies.

Cramer--Rao Bounds for Magneto-Inductive Integrated Sensing and Communications

Magnetic induction (MI) enables communication in RF-denied environments (underground, underwater, in-body), where the medium conductivity imprints a deterministic signature on the channel. This letter derives a closed-form Cramér--Rao bound (CRB) for the joint estimation of range and medium conductivity from MI pilot observations in an integrated sensing and communication (ISAC) framework. The Fisher information matrix reveals that the joint estimation penalty converges to 3\,dB in the near-field regime, meaning conductivity sensing adds at most a factor-of-two loss in ranging precision. Monte Carlo maximum-likelihood simulations confirm that the CRB is achievable under practical operating conditions.

MI-ISAC: Magneto-Inductive Integrated Sensing and Communication in the Reactive Near-Field for RF-Denied Environments

Radio-frequency integrated sensing and communication (RF-ISAC) is ineffective inunderground, underwater, and in-body environments where conductive media attenuate electromagnetic waves by tens of dB per meter. This article presents magneto-inductive ISAC (MI-ISAC), a paradigm that exploits the reactive near-field quasi-static coupling inherent to MI links, enabling a fundamentally different approach to ISAC in these RF-denied environments. Five foundational results are established: (i)~tri-axial coils are necessary and sufficient for identifiable joint range-and-angle estimation; (ii)~coupling strength changes sharply with range, enabling theoretical sub-millimeter accuracy at typical MI distances despite kHz-level bandwidth; (iii)~time-of-flight is ineffective under such narrow bandwidth, but the coupling gradient provides approximately six orders of magnitude finer resolution; (iv)~MI-ISAC can provide 4--10+\,dB sensing gain over time-division baselines; and (v)~the MI-MIMO channel is geometry-invariant and well-conditioned across all orientations. Applications and a research roadmap are discussed.

Information Theoretic Modeling of Interspecies Molecular Communication

Plants and insects communicate using chemical signals like volatile organic compounds (VOCs). A plant encodes information using different blends of VOCs, which propagate through the air to represent different symbolic information. This communication occurs in a noisy environment, characterized by wind, distance, and complex biological reactions. At the receiver, cross-reactive olfactory receptors produce stochastic binding events whose discretized durations form the receiver observation. In this paper, an information-theoretic framework is developed to model interspecies molecular communication (MC), where receptor responses are modeled probabilistically using a multinomial distribution. Numerical results show that the communication depends on environmental parameters such as wind speed, distance, and the number of released molecules. The proposed framework provides fundamental insights into the VOC-based interspecies communication under realistic biological and environmental conditions.

Channel Modeling and Experimental Validation of Odor-Based Molecular Communication Systems

Odor-based Molecular Communication (OMC) employs odor molecules to convey information, contributing to the realization of the Internet of Everything (IoE) vision. Despite this, the practical deployment of OMC systems is currently limited by the lack of comprehensive channel models that accurately characterize particle propagation in diverse environments. While existing literature explores various aspects of molecular transport, a holistic approach that integrates theoretical modeling with experimental validation for bounded channels remains underdeveloped. In this paper, we address this gap by proposing mathematical frameworks for both bounded and unbounded OMC channels. To verify the accuracy of the proposed models, we develop a novel experimental testbed and conduct an extensive performance analysis. Our results demonstrate a strong correlation between the theoretical derivations and experimental data, providing a robust foundation for the design and analysis of future end-to-end OMC systems.

Intrinsic MIMO Particle Communication Channel with Random Advection

In this work, receiver diversity in advection-dominated diffusion-advection channels is investigated. Strong directed flow fundamentally alters the communication-theoretic properties of molecular communication systems (MC). Specifically, advection preserves the temporal ordering and shape of transmitted pulses, enabling pulse-based and higher-order modulation schemes that are typically infeasible in purely diffusive environments. Focusing on a single transmitter and a single type of information molecule, it is demonstrated that spatially distributed receivers can observe distinct realizations of the same transmitted signal, giving rise to diversity gain. Several receiver combining strategies are evaluated and shown to improve detection performance compared to single-receiver operation, particularly in low-to-moderate signal-to-noise ratio (SNR) regimes. The results provide a structured framework for understanding receiver-side diversity in molecular communication, highlighting the role of advection as a key enabler for reliable pulse-based signaling. This perspective establishes a foundation for future studies on advanced modulation, joint equalization and detection, and multi-molecule MIMO extensions that can further enhance the performance and physical applicability of MC systems.

Neural-Inspired Multi-Agent Molecular Communication Networks for Collective Intelligence

Molecular Communication (MC) is a pivotal enabler for the Internet of Bio-Nano Things (IoBNT). However, current research often relies on super-capable individual agents with complex transceiver architectures that defy the energy and processing constraints of realistic nanomachines. This paper proposes a paradigm shift towards collective intelligence, inspired by the cortical networks of the biological brain. We introduce a decentralized network architecture where simple nanomachines interact via a diffusive medium using a threshold-based firing mechanism modeled by Greenberg-Hastings (GH) cellular automata. We derive fixed-point equations for steady-state populations via mean-field analysis and validate them against stochastic simulations. We demonstrate that the network undergoes a second-order phase transition at a specific activation threshold. Crucially, we show that both pairwise and collective mutual information peak exactly at this critical transition point, confirming that the system maximizes information propagation and processing capacity at the edge of chaos.

Airborne Particle Communication Through Time-varying Diffusion-Advection Channels

Particle based communication using diffusion and advection has emerged as an alternative signaling paradigm recently. While most existing studies assume constant flow conditions, real macro scale environments such as atmospheric winds exhibit time varying behavior. In this work, airborne particle communication under time varying advection is modeled as a linear time varying (LTV) channel, and a closed form, time dependent channel impulse response is derived using the method of moving frames. Based on this formulation, the channel is characterized through its power delay profile, leading to the definition of channel dispersion time as a physically meaningful measure of channel memory and a guideline for symbol duration selection. System level simulations under directed, time varying wind conditions show that waveform design is critical for performance, enabling multi symbol modulation using a single particle type when dispersion is sufficiently controlled. The results demonstrate that time varying diffusion advection channels can be systematically modeled and engineered using communication theoretic tools, providing a realistic foundation for particle based communication in complex flow environments.

Physical Limits of Proximal Tumor Detection via MAGE-A Extracellular Vesicles

Early cancer detection relies on invasive tissue biopsies or liquid biopsies limited by biomarker dilution. In contrast, tumour-derived extracellular vesicles (EVs) carrying biomarkers like melanoma-associated antigen-A (MAGE-A) are highly concentrated in the peri-tumoral interstitial space, offering a promising near-field target. However, at micrometre scales, EV transport is governed by stochastic diffusion in a low copy number regime, increasing the risk of false negatives. We theoretically assess the feasibility of a smart-needle sensor detecting MAGE-A-positive microvesicles near a tumour. We use a hybrid framework combining particle-based Brownian dynamics (Smoldyn) to quantify stochastic arrival and false negative probabilities, and a reaction-diffusion PDE for mean concentration profiles. Formulating detection as a threshold-based binary hypothesis test, we find a maximum feasible detection radius of approximately 275 micrometers for a 6000 s sensing window. These results outline the physical limits of proximal EV-based detection and inform the design of minimally invasive peri-tumoral sensors.