Longitudinal Risk Prediction in Mammography with Privileged History Distillation

Breast cancer remains a leading cause of cancer-related mortality worldwide. Longitudinal mammography risk prediction models improve multi-year breast cancer risk prediction based on prior screening exams. However, in real-world clinical practice, longitudinal histories are often incomplete, irregular, or unavailable due to missed screenings, first-time examinations, heterogeneous acquisition schedules, or archival constraints. The absence of prior exams degrades the performance of longitudinal risk models and limits their practical applicability. While substantial longitudinal history is available during training, prior exams are commonly absent at test time. In this paper, we address missing history at inference time and propose a longitudinal risk prediction method that uses mammography history as privileged information during training and distills its prognostic value into a student model that only requires the current exam at inference time. The key idea is a privileged multi-teacher distillation scheme with horizon-specific teachers: each teacher is trained on the full longitudinal history to specialize in one prediction horizon, while the student receives only a reconstructed history derived from the current exam. This allows the student to inherit horizon-dependent longitudinal risk cues without requiring prior screening exams at deployment. Our new Privileged History Distillation (PHD) method is validated on a large longitudinal mammography dataset with multi-year cancer outcomes, CSAW-CC, comparing full-history and no-history baselines to their distilled counterparts. Using time-dependent AUC across horizons, our privileged history distillation method markedly improves the performance of long-horizon prediction over no-history models and is comparable to that of full-history models, while using only the current exam at inference time.

Adaptation of Weakly Supervised Localization in Histopathology by Debiasing Predictions

Weakly Supervised Object Localization (WSOL) models enable joint classification and region-of-interest localization in histology images using only image-class supervision. When deployed in a target domain, distributions shift remains a major cause of performance degradation, especially when applied on new organs or institutions with different staining protocols and scanner characteristics. Under stronger cross-domain shifts, WSOL predictions can become biased toward dominant classes, producing highly skewed pseudo-label distributions in the target domain. Source-Free (Unsupervised) Domain Adaptation (SFDA) methods are commonly employed to address domain shift. However, because they rely on self-training, the initial bias is reinforced over training iterations, degrading both classification and localization tasks. We identify this amplification of prediction bias as a primary obstacle to the SFDA of WSOL models in histopathology. This paper introduces \sfdadep, a method inspired by machine unlearning that formulates SFDA as an iterative process of identifying and correcting prediction bias. It periodically identifies target images from over-predicted classes and selectively reduces the predictive confidence for uncertain (high entropy) images, while preserving confident predictions. This process reduces the drift of decision boundaries and bias toward dominant classes. A jointly optimized pixel-level classifier further restores discriminative localization features under distribution shift. Extensive experiments on cross-organ and -center histopathology benchmarks (glas, CAMELYON-16, CAMELYON-17) with several WSOL models show that SFDA-DeP consistently improves classification and localization over state-of-the-art SFDA baselines. {\small Code: \href{https://anonymous.4open.science/r/SFDA-DeP-1797/}{anonymous.4open.science/r/SFDA-DeP-1797/}}

MuSACo: Multimodal Subject-Specific Selection and Adaptation for Expression Recognition with Co-Training

Personalized expression recognition (ER) involves adapting a machine learning model to subject-specific data for improved recognition of expressions with considerable interpersonal variability. Subject-specific ER can benefit significantly from multi-source domain adaptation (MSDA) methods, where each domain corresponds to a specific subject, to improve model accuracy and robustness. Despite promising results, state-of-the-art MSDA approaches often overlook multimodal information or blend sources into a single domain, limiting subject diversity and failing to explicitly capture unique subject-specific characteristics. To address these limitations, we introduce MuSACo, a multi-modal subject-specific selection and adaptation method for ER based on co-training. It leverages complementary information across multiple modalities and multiple source domains for subject-specific adaptation. This makes MuSACo particularly relevant for affective computing applications in digital health, such as patient-specific assessment for stress or pain, where subject-level nuances are crucial. MuSACo selects source subjects relevant to the target and generates pseudo-labels using the dominant modality for class-aware learning, in conjunction with a class-agnostic loss to learn from less confident target samples. Finally, source features from each modality are aligned, while only confident target features are combined. Our experimental results on challenging multimodal ER datasets: BioVid and StressID, show that MuSACo can outperform UDA (blending) and state-of-the-art MSDA methods.