Towards Biologically Plausible and Private Gene Expression Data Generation

Generative models trained with Differential Privacy (DP) are becoming increasingly prominent in the creation of synthetic data for downstream applications. Existing literature, however, primarily focuses on basic benchmarking datasets and tends to report promising results only for elementary metrics and relatively simple data distributions. In this paper, we initiate a systematic analysis of how DP generative models perform in their natural application scenarios, specifically focusing on real-world gene expression data. We conduct a comprehensive analysis of five representative DP generation methods, examining them from various angles, such as downstream utility, statistical properties, and biological plausibility. Our extensive evaluation illuminates the unique characteristics of each DP generation method, offering critical insights into the strengths and weaknesses of each approach, and uncovering intriguing possibilities for future developments. Perhaps surprisingly, our analysis reveals that most methods are capable of achieving seemingly reasonable downstream utility, according to the standard evaluation metrics considered in existing literature. Nevertheless, we find that none of the DP methods are able to accurately capture the biological characteristics of the real dataset. This observation suggests a potential over-optimistic assessment of current methodologies in this field and underscores a pressing need for future enhancements in model design.

Architecting Safety Supervisors for High Levels of Automated Driving

The complexity of automated driving poses challenges for providing safety assurance. Focusing on the architecting of an Autonomous Driving Intelligence (ADI), i.e. the computational intelligence, sensors and communication needed for high levels of automated driving, we investigate so called safety supervisors that complement the nominal functionality. We present a problem formulation and a functional architecture of a fault-tolerant ADI that encompasses a nominal and a safety supervisor channel. We then discuss the sources of hazardous events, the division of responsibilities among the channels, and when the supervisor should take over. We conclude with identified directions for further work.