Embracing Aleatoric Uncertainty in Medical Multimodal Learning with Missing Modalities

Medical multimodal learning faces significant challenges with missing modalities prevalent in clinical practice. Existing approaches assume equal contribution of modality and random missing patterns, neglecting inherent uncertainty in medical data acquisition. In this regard, we propose the Aleatoric Uncertainty Modeling (AUM) that explicitly quantifies unimodal aleatoric uncertainty to address missing modalities. Specifically, AUM models each unimodal representation as a multivariate Gaussian distribution to capture aleatoric uncertainty and enable principled modality reliability quantification. To adaptively aggregate captured information, we develop a dynamic message-passing mechanism within a bipartite patient-modality graph using uncertainty-aware aggregation mechanism. Through this process, missing modalities are naturally accommodated, while more reliable information from available modalities is dynamically emphasized to guide representation generation. Our AUM framework achieves an improvement of 2.26% AUC-ROC on MIMIC-IV mortality prediction and 2.17% gain on eICU, outperforming existing state-of-the-art approaches.

Robust Multimodal Representation Learning in Healthcare

Medical multimodal representation learning aims to integrate heterogeneous data into unified patient representations to support clinical outcome prediction. However, real-world medical datasets commonly contain systematic biases from multiple sources, which poses significant challenges for medical multimodal representation learning. Existing approaches typically focus on effective multimodal fusion, neglecting inherent biased features that affect the generalization ability. To address these challenges, we propose a Dual-Stream Feature Decorrelation Framework that identifies and handles the biases through structural causal analysis introduced by latent confounders. Our method employs a causal-biased decorrelation framework with dual-stream neural networks to disentangle causal features from spurious correlations, utilizing generalized cross-entropy loss and mutual information minimization for effective decorrelation. The framework is model-agnostic and can be integrated into existing medical multimodal learning methods. Comprehensive experiments on MIMIC-IV, eICU, and ADNI datasets demonstrate consistent performance improvements.

Feature Calibration enhanced Parameter Synthesis for CLIP-based Class-incremental Learning

Class-incremental Learning (CIL) enables models to continuously learn new class knowledge while memorizing previous classes, facilitating their adaptation and evolution in dynamic environments. Traditional CIL methods are mainly based on visual features, which limits their ability to handle complex scenarios. In contrast, Vision-Language Models (VLMs) show promising potential to promote CIL by integrating pretrained knowledge with textual features. However, previous methods make it difficult to overcome catastrophic forgetting while preserving the generalization capabilities of VLMs. To tackle these challenges, we propose Feature Calibration enhanced Parameter Synthesis (FCPS) in this paper. Specifically, our FCPS employs a specific parameter adjustment mechanism to iteratively refine the proportion of original visual features participating in the final class determination, ensuring the model's foundational generalization capabilities. Meanwhile, parameter integration across different tasks achieves a balance between learning new class knowledge and retaining old knowledge. Experimental results on popular benchmarks (e.g., CIFAR100 and ImageNet100) validate the superiority of the proposed method.