HyperCLOVA X Technical Report

We introduce HyperCLOVA X, a family of large language models (LLMs) tailored to the Korean language and culture, along with competitive capabilities in English, math, and coding. HyperCLOVA X was trained on a balanced mix of Korean, English, and code data, followed by instruction-tuning with high-quality human-annotated datasets while abiding by strict safety guidelines reflecting our commitment to responsible AI. The model is evaluated across various benchmarks, including comprehensive reasoning, knowledge, commonsense, factuality, coding, math, chatting, instruction-following, and harmlessness, in both Korean and English. HyperCLOVA X exhibits strong reasoning capabilities in Korean backed by a deep understanding of the language and cultural nuances. Further analysis of the inherent bilingual nature and its extension to multilingualism highlights the model's cross-lingual proficiency and strong generalization ability to untargeted languages, including machine translation between several language pairs and cross-lingual inference tasks. We believe that HyperCLOVA X can provide helpful guidance for regions or countries in developing their sovereign LLMs.

Computational Approaches for Predicting Drug-Disease Associations: A Comprehensive Review

In recent decades, traditional drug research and development have been facing challenges such as high cost, long timelines, and high risks. To address these issues, many computational approaches have been suggested for predicting the relationship between drugs and diseases through drug repositioning, aiming to reduce the cost, development cycle, and risks associated with developing new drugs. Researchers have explored different computational methods to predict drug-disease associations, including drug side effects-disease associations, drug-target associations, and miRNAdisease associations. In this comprehensive review, we focus on recent advances in predicting drug-disease association methods for drug repositioning. We first categorize these methods into several groups, including neural network-based algorithms, matrixbased algorithms, recommendation algorithms, link-based reasoning algorithms, and text mining and semantic reasoning. Then, we compare the prediction performance of existing drug-disease association prediction algorithms. Lastly, we delve into the present challenges and future prospects concerning drug-disease associations.

Deep Learning and Inverse Problems

Machine Learning (ML) methods and tools have gained great success in many data, signal, image and video processing tasks, such as classification, clustering, object detection, semantic segmentation, language processing, Human-Machine interface, etc. In computer vision, image and video processing, these methods are mainly based on Neural Networks (NN) and in particular Convolutional NN (CNN), and more generally Deep NN. Inverse problems arise anywhere we have indirect measurement. As, in general, those inverse problems are ill-posed, to obtain satisfactory solutions for them needs prior information. Different regularization methods have been proposed, where the problem becomes the optimization of a criterion with a likelihood term and a regularization term. The main difficulty, however, in great dimensional real applications, remains the computational cost. Using NN, and in particular Deep Learning (DL) surrogate models and approximate computation, can become very helpful. In this work, we focus on NN and DL particularly adapted for inverse problems. We consider two cases: First the case where the forward operator is known and used as physics constraint, the second more general data driven DL methods.

Deep Learning and Bayesian inference for Inverse Problems

Inverse problems arise anywhere we have indirect measurement. As, in general they are ill-posed, to obtain satisfactory solutions for them needs prior knowledge. Classically, different regularization methods and Bayesian inference based methods have been proposed. As these methods need a great number of forward and backward computations, they become costly in computation, in particular, when the forward or generative models are complex and the evaluation of the likelihood becomes very costly. Using Deep Neural Network surrogate models and approximate computation can become very helpful. However, accounting for the uncertainties, we need first understand the Bayesian Deep Learning and then, we can see how we can use them for inverse problems. In this work, we focus on NN, DL and more specifically the Bayesian DL particularly adapted for inverse problems. We first give details of Bayesian DL approximate computations with exponential families, then we will see how we can use them for inverse problems. We consider two cases: First the case where the forward operator is known and used as physics constraint, the second more general data driven DL methods. keyword: Neural Network, Variational Bayesian inference, Bayesian Deep Learning (DL), Inverse problems, Physics based DL.

Road Extraction with Satellite Images and Partial Road Maps

Road extraction is a process of automatically generating road maps mainly from satellite images. Existing models all target to generate roads from the scratch despite that a large quantity of road maps, though incomplete, are publicly available (e.g. those from OpenStreetMap) and can help with road extraction. In this paper, we propose to conduct road extraction based on satellite images and partial road maps, which is new. We then propose a two-branch Partial to Complete Network (P2CNet) for the task, which has two prominent components: Gated Self-Attention Module (GSAM) and Missing Part (MP) loss. GSAM leverages a channel-wise self-attention module and a gate module to capture long-range semantics, filter out useless information, and better fuse the features from two branches. MP loss is derived from the partial road maps, trying to give more attention to the road pixels that do not exist in partial road maps. Extensive experiments are conducted to demonstrate the effectiveness of our model, e.g. P2CNet achieves state-of-the-art performance with the IoU scores of 70.71% and 75.52%, respectively, on the SpaceNet and OSM datasets.

BARS: A Benchmark for Airport Runway Segmentation

Airport runway segmentation can effectively reduce the accident rate during the landing phase, which has the largest risk of flight accidents. With the rapid development of deep learning, related methods have good performance on segmentation tasks and can be well adapted to complex scenes. However, the lack of large-scale, publicly available datasets in this field makes the development of methods based on deep learning difficult. Therefore, we propose a Benchmark for Airport Runway Segmentation, named BARS. Meanwhile, a semi-automatic annotation pipeline is designed to reduce the workload of annotation. BARS has the largest dataset with the richest categories and the only instance annotation in the field. The dataset, which is collected using the X-Plane simulation platform, contains 10,002 images and 29,347 instances with three categories. We evaluate eight representative instance segmentation methods on BARS and analyze their performance. Based on the characteristic of the airport runway with a regular shape, we propose a plug-and-play smoothing post-processing module (SPPM) and a contour point constraint loss (CPCL) function to smooth segmentation results for mask-based and contour-based methods, respectively. Furthermore, a novel evaluation metric named average smoothness (AS) is developed to measure smoothness. The experiments show that existing instance segmentation methods can achieve prediction results with good performance on BARS. SPPM and CPCL can improve the average accuracy by 0.9% and 1.13%, respectively. And the average smoothness enhancements for SPPM and CPCL are more than 50% and 28%, respectively. Our work will be released at https://github.com/c-wenhui/BARS.

Multi-Agent Deep Reinforcement Learning for HVAC Control in Commercial Buildings

In commercial buildings, about 40%-50% of the total electricity consumption is attributed to Heating, Ventilation, and Air Conditioning (HVAC) systems, which places an economic burden on building operators. In this paper, we intend to minimize the energy cost of an HVAC system in a multi-zone commercial building under dynamic pricing with the consideration of random zone occupancy, thermal comfort, and indoor air quality comfort. Due to the existence of unknown thermal dynamics models, parameter uncertainties (e.g., outdoor temperature, electricity price, and number of occupants), spatially and temporally coupled constraints associated with indoor temperature and CO2 concentration, a large discrete solution space, and a non-convex and non-separable objective function, it is very challenging to achieve the above aim. To this end, the above energy cost minimization problem is reformulated as a Markov game. Then, an HVAC control algorithm is proposed to solve the Markov game based on multi-agent deep reinforcement learning with attention mechanism. The proposed algorithm does not require any prior knowledge of uncertain parameters and can operate without knowing building thermal dynamics models. Simulation results based on real-world traces show the effectiveness, robustness and scalability of the proposed algorithm.

A Node Embedding Framework for Integration of Similarity-based Drug Combination Prediction

Motivation: Drug combination is a sensible strategy for disease treatment by improving the efficacy and reducing concomitant side effects. Due to the large number of possible combinations among candidate compounds, exhaustive screening is prohibitive. Currently, a plenty of studies have focused on predicting potential drug combinations. However, these methods are not entirely satisfactory in performance and scalability. Results: In this paper, we proposed a Network Embedding framework in Multiplex Networks (NEMN) to predict synthetic drug combinations. Based on a multiplex drug similarity network, we offered alternative methods to integrate useful information from different aspects and to decide quantitative importance of each network. To explain the feasibility of NEMN, we applied our framework to the data of drug-drug interactions, on which it showed better performance in terms of AUPR and ROC. For Drug combination prediction, we found seven novel drug combinations which have been validated by external sources among the top-ranked predictions of our model.

Deep Learning System to Screen Coronavirus Disease 2019 Pneumonia

We found that the real time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab has a relatively low positive rate in the early stage to determine COVID-19 (named by the World Health Organization). The manifestations of computed tomography (CT) imaging of COVID-19 had their own characteristics, which are different from other types of viral pneumonia, such as Influenza-A viral pneumonia. Therefore, clinical doctors call for another early diagnostic criteria for this new type of pneumonia as soon as possible.This study aimed to establish an early screening model to distinguish COVID-19 pneumonia from Influenza-A viral pneumonia and healthy cases with pulmonary CT images using deep learning techniques. The candidate infection regions were first segmented out using a 3-dimensional deep learning model from pulmonary CT image set. These separated images were then categorized into COVID-19, Influenza-A viral pneumonia and irrelevant to infection groups, together with the corresponding confidence scores using a location-attention classification model. Finally the infection type and total confidence score of this CT case were calculated with Noisy-or Bayesian function.The experiments result of benchmark dataset showed that the overall accuracy was 86.7 % from the perspective of CT cases as a whole.The deep learning models established in this study were effective for the early screening of COVID-19 patients and demonstrated to be a promising supplementary diagnostic method for frontline clinical doctors.