Development, Evaluation, and Deployment of a Multi-Agent System for Thoracic Tumor Board

Tumor boards are multidisciplinary conferences dedicated to producing actionable patient care recommendations with live review of primary radiology and pathology data. Succinct patient case summaries are needed to drive efficient and accurate case discussions. We developed a manual AI-based workflow to generate patient summaries to display live at the Stanford Thoracic Tumor board. To improve on this manually intensive process, we developed several automated AI chart summarization methods and evaluated them against physician gold standard summaries and fact-based scoring rubrics. We report these comparative evaluations as well as our deployment of the final state automated AI chart summarization tool along with post-deployment monitoring. We also validate the use of an LLM as a judge evaluation strategy for fact-based scoring. This work is an example of integrating AI-based workflows into routine clinical practice.

A Multimodal Foundation Model of Spatial Transcriptomics and Histology for Biological Discovery and Clinical Prediction

Spatial transcriptomics (ST) enables gene expression mapping within anatomical context but remains costly and low-throughput. Hematoxylin and eosin (H\&E) staining offers rich morphology yet lacks molecular resolution. We present \textbf{\ours} (\textbf{S}patial \textbf{T}ranscriptomics and hist\textbf{O}logy \textbf{R}epresentation \textbf{M}odel), a foundation model trained on 1.2 million spatially resolved transcriptomic profiles with matched histology across 18 organs. Using a hierarchical architecture integrating morphological features, gene expression, and spatial context, STORM bridges imaging and omics through robust molecular--morphological representations. STORM enhances spatial domain discovery, producing biologically coherent tissue maps, and outperforms existing methods in predicting spatial gene expression from H\&E images across 11 tumor types. The model is platform-agnostic, performing consistently across Visium, Xenium, Visium HD, and CosMx. Applied to 23 independent cohorts comprising 7,245 patients, STORM significantly improves immunotherapy response prediction and prognostication over established biomarkers, providing a scalable framework for spatially informed discovery and clinical precision medicine.