HARBOR: Automated Harness Optimization

Long-horizon language-model agents are dominated, in lines of code and in operational complexity, not by their underlying model but by the harness that wraps it: context compaction, tool caching, semantic memory, trajectory reuse, speculative tool prediction, and the glue that binds the model to a sandboxed execution environment. We argue that harness design is a first-class machine-learning problem and that automated configuration search dominates manual stacking once the flag space exceeds a handful of bits. We defend this claim in two steps. First, we formalize automated harness optimization as constrained noisy Bayesian optimization over a mixed-variable, cost-heterogeneous configuration space with cold-start-corrected rewards and a posterior chance-constrained safety check, and give a reference solver, HARBOR (Harness Axis-aligned Regularized Bayesian Optimization Routine), built from a block-additive SAAS surrogate, multi-fidelity cost-aware acquisition, and TuRBO trust regions. Second, we instantiate the problem in a flag-gated harness over a production coding agent and report a controlled four-round manual-tuning case study against a fixed task suite and an end-to-end HARBOR run. The formulation itself is task-class agnostic: the configuration space, reward correction, acquisition, and safety check apply to any agent harness with a bounded flag space and a reproducible task suite.

From Translation to Superset: Benchmark-Driven Evolution of a Production AI Agent from Rust to Python

Cross-language migration of large software systems is a persistent engineering challenge, particularly when the source codebase evolves rapidly. We present a methodology for LLM-assisted continuous code translation in which a large language model translates a production Rust codebase (648K LOC, 65 crates) into Python (41K LOC, 28 modules), with public agent benchmarks as the objective function driving iterative refinement. Our subject system is Codex CLI, a production AI coding agent. We demonstrate that: (1) the Python port resolves 59/80 SWE-bench Verified tasks (73.8%) versus Rust's 56/80 (70.0%), and achieves 42.5% on Terminal-Bench versus Rust's 47.5%, confirming near-parity on real-world agentic tasks; (2) benchmark-driven debugging, revealing API protocol mismatches, environment pollution, a silent WebSocket failure mode, and an API 400 crash, is more effective than static testing alone; (3) the architecture supports continuous upstream synchronisation via an LLM-assisted diff-translate-test loop; and (4) the Python port has evolved into a capability superset with 30 feature-flagged extensions (multi-agent orchestration, semantic memory, guardian safety, cost tracking) absent from Rust, while preserving strict parity mode for comparison. Our evaluation shows that for LLM-based agents where API latency dominates, Python's expressiveness yields a 15.9x code reduction with negligible performance cost, while the benchmark-as-objective-function methodology provides a principled framework for growing a cross-language port from parity into an extended platform.

DeepFAN, a transformer-based deep learning model for human-artificial intelligence collaborative assessment of incidental pulmonary nodules in CT scans: a multi-reader, multi-case trial

The widespread adoption of CT has notably increased the number of detected lung nodules. However, current deep learning methods for classifying benign and malignant nodules often fail to comprehensively integrate global and local features, and most of them have not been validated through clinical trials. To address this, we developed DeepFAN, a transformer-based model trained on over 10K pathology-confirmed nodules and further conducted a multi-reader, multi-case clinical trial to evaluate its efficacy in assisting junior radiologists. DeepFAN achieved diagnostic area under the curve (AUC) of 0.939 (95% CI 0.930-0.948) on an internal test set and 0.954 (95% CI 0.934-0.973) on the clinical trial dataset involving 400 cases across three independent medical institutions. Explainability analysis indicated higher contributions from global than local features. Twelve readers' average performance significantly improved by 10.9% (95% CI 8.3%-13.5%) in AUC, 10.0% (95% CI 8.9%-11.1%) in accuracy, 7.6% (95% CI 6.1%-9.2%) in sensitivity, and 12.6% (95% CI 10.9%-14.3%) in specificity (P<0.001 for all). Nodule-level inter-reader diagnostic consistency improved from fair to moderate (overall k: 0.313 vs. 0.421; P=0.019). In conclusion, DeepFAN effectively assisted junior radiologists and may help homogenize diagnostic quality and reduce unnecessary follow-up of indeterminate pulmonary nodules. Chinese Clinical Trial Registry: ChiCTR2400084624.