ChronoMedicalWorld: A Medical World Model for Learning Patient Trajectories from Longitudinal Care Data

Long-horizon clinical simulation -- predicting how a patient's physiology evolves over years under specified interventions -- is central to chronic-disease care, yet existing electronic health record (EHR) models are predominantly discriminative, and general-purpose large language models drift under repeated interventions. We propose the \textbf{ChronoMedicalWorld Model (CMWM)}, an action-conditioned latent world-model framework for learning patient trajectories from longitudinal care data. CMWM couples a joint-embedding state encoder with a wide action encoder that admits both structured intervention indicators and free-text communication embeddings, and trains a recurrent latent transition module under a six-term objective: next-observation supervision, next-latent prediction, SIGReg latent regularisation, and three physiology-aware shape priors (slope, continuity, large-jump penalty). A closed-loop rollout-prefix protocol matches training to deployment, so the model is optimised against the same multi-step error it exhibits at inference. As a concrete case study, we instantiate CMWM for annual estimated glomerular filtration rate (eGFR) trajectory forecasting in chronic kidney disease (CKD). On a 2{,}232-patient nephrology cohort, the CKD instantiation achieves a dynamic-50\% history rollout test mean absolute error (MAE) of 7.384 and root-mean-square error (RMSE) of 10.256, against 7.964 and 11.069 for a tuned GPT-5.5 structured-prompting baseline ($-7.28\%$ MAE, $-7.35\%$ RMSE), with the gain dominated by the dialogue portion of patient--health-coach communication. The framework is not CKD-specific: its architecture, loss design, and training protocol apply to any chronic condition that can be cast as periodic clinical state interleaved with structured and conversational interventions.

ProductResearch: Training E-Commerce Deep Research Agents via Multi-Agent Synthetic Trajectory Distillation

Large Language Model (LLM)-based agents show promise for e-commerce conversational shopping, yet existing implementations lack the interaction depth and contextual breadth required for complex product research. Meanwhile, the Deep Research paradigm, despite advancing information synthesis in web search, suffers from domain gaps when transferred to e-commerce. We propose ProductResearch, a multi-agent framework that synthesizes high-fidelity, long-horizon tool-use trajectories for training robust e-commerce shopping agents. The framework employs a User Agent to infer nuanced shopping intents from behavioral histories, and a Supervisor Agent that orchestrates iterative collaboration with a Research Agent to generate synthetic trajectories culminating in comprehensive, insightful product research reports. These trajectories are rigorously filtered and distilled through a reflective internalization process that consolidates multi-agent supervisory interactions into coherent single-role training examples, enabling effective fine-tuning of LLM agents for complex shopping inquiries. Extensive experiments show that a compact MoE model fine-tuned on our synthetic data achieves substantial improvements over its base model in response comprehensiveness, research depth, and user-perceived utility, approaching the performance of frontier proprietary deep research systems and establishing multi-agent synthetic trajectory training as an effective and scalable paradigm for enhancing LLM-based shopping assistance.