Challenges and opportunities in applying Neural Temporal Point Processes to large scale industry data

In this work, we identify open research opportunities in applying Neural Temporal Point Process (NTPP) models to industry scale customer behavior data by carefully reproducing NTPP models published up to date on known literature benchmarks as well as applying NTPP models to a novel, real world consumer behavior dataset that is twice as large as the largest publicly available NTPP benchmark. We identify the following challenges. First, NTPP models, albeit their generative nature, remain vulnerable to dataset imbalances and cannot forecast rare events. Second, NTPP models based on stochastic differential equations, despite their theoretical appeal and leading performance on literature benchmarks, do not scale easily to large industry-scale data. The former is in light of previously made observations on deep generative models. Additionally, to combat a cold-start problem, we explore a novel addition to NTPP models - a parametrization based on static user features.

Multiple Instance Captioning: Learning Representations from Histopathology Textbooks and Articles

We present ARCH, a computational pathology (CP) multiple instance captioning dataset to facilitate dense supervision of CP tasks. Existing CP datasets focus on narrow tasks; ARCH on the other hand contains dense diagnostic and morphological descriptions for a range of stains, tissue types and pathologies. Using intrinsic dimensionality estimation, we show that ARCH is the only CP dataset to (ARCH-)rival its computer vision analog MS-COCO Captions. We conjecture that an encoder pre-trained on dense image captions learns transferable representations for most CP tasks. We support the conjecture with evidence that ARCH representation transfers to a variety of pathology sub-tasks better than ImageNet features or representations obtained via self-supervised or multi-task learning on pathology images alone. We release our best model and invite other researchers to test it on their CP tasks.

Predicting Landsat Reflectance with Deep Generative Fusion

Public satellite missions are commonly bound to a trade-off between spatial and temporal resolution as no single sensor provides fine-grained acquisitions with frequent coverage. This hinders their potential to assist vegetation monitoring or humanitarian actions, which require detecting rapid and detailed terrestrial surface changes. In this work, we probe the potential of deep generative models to produce high-resolution optical imagery by fusing products with different spatial and temporal characteristics. We introduce a dataset of co-registered Moderate Resolution Imaging Spectroradiometer (MODIS) and Landsat surface reflectance time series and demonstrate the ability of our generative model to blend coarse daily reflectance information into low-paced finer acquisitions. We benchmark our proposed model against state-of-the-art reflectance fusion algorithms.

Exoplanet Validation with Machine Learning: 50 new validated Kepler planets

Over 30% of the ~4000 known exoplanets to date have been discovered using 'validation', where the statistical likelihood of a transit arising from a false positive (FP), non-planetary scenario is calculated. For the large majority of these validated planets calculations were performed using the vespa algorithm (Morton et al. 2016). Regardless of the strengths and weaknesses of vespa, it is highly desirable for the catalogue of known planets not to be dependent on a single method. We demonstrate the use of machine learning algorithms, specifically a gaussian process classifier (GPC) reinforced by other models, to perform probabilistic planet validation incorporating prior probabilities for possible FP scenarios. The GPC can attain a mean log-loss per sample of 0.54 when separating confirmed planets from FPs in the Kepler threshold crossing event (TCE) catalogue. Our models can validate thousands of unseen candidates in seconds once applicable vetting metrics are calculated, and can be adapted to work with the active TESS mission, where the large number of observed targets necessitates the use of automated algorithms. We discuss the limitations and caveats of this methodology, and after accounting for possible failure modes newly validate 50 Kepler candidates as planets, sanity checking the validations by confirming them with vespa using up to date stellar information. Concerning discrepancies with vespa arise for many other candidates, which typically resolve in favour of our models. Given such issues, we caution against using single-method planet validation with either method until the discrepancies are fully understood.

Multi-Task Learning in Histo-pathology for Widely Generalizable Model

In this work we show preliminary results of deep multi-task learning in the area of computational pathology. We combine 11 tasks ranging from patch-wise oral cancer classification, one of the most prevalent cancers in the developing world, to multi-tissue nuclei instance segmentation and classification.

PanNuke Dataset Extension, Insights and Baselines

The emerging area of computational pathology (CPath) is ripe ground for the application of deep learning (DL) methods to healthcare due to the sheer volume of raw pixel data in whole-slide images (WSIs) of cancerous tissue slides. However, it is imperative for the DL algorithms relying on nuclei-level details to be able to cope with data from `the clinical wild', which tends to be quite challenging. We study, and extend recently released PanNuke dataset consisting of ~200,000 nuclei categorized into 5 clinically important classes for the challenging tasks of segmenting and classifying nuclei in WSIs. Previous pan-cancer datasets consisted of only up to 9 different tissues and up to 21,000 unlabeled nuclei and just over 24,000 labeled nuclei with segmentation masks. PanNuke consists of 19 different tissue types that have been semi-automatically annotated and quality controlled by clinical pathologists, leading to a dataset with statistics similar to the clinical wild and with minimal selection bias. We study the performance of segmentation and classification models when applied to the proposed dataset and demonstrate the application of models trained on PanNuke to whole-slide images. We provide comprehensive statistics about the dataset and outline recommendations and research directions to address the limitations of existing DL tools when applied to real-world CPath applications.