CARE-PD: A Multi-Site Anonymized Clinical Dataset for Parkinson's Disease Gait Assessment

Objective gait assessment in Parkinson's Disease (PD) is limited by the absence of large, diverse, and clinically annotated motion datasets. We introduce CARE-PD, the largest publicly available archive of 3D mesh gait data for PD, and the first multi-site collection spanning 9 cohorts from 8 clinical centers. All recordings (RGB video or motion capture) are converted into anonymized SMPL meshes via a harmonized preprocessing pipeline. CARE-PD supports two key benchmarks: supervised clinical score prediction (estimating Unified Parkinson's Disease Rating Scale, UPDRS, gait scores) and unsupervised motion pretext tasks (2D-to-3D keypoint lifting and full-body 3D reconstruction). Clinical prediction is evaluated under four generalization protocols: within-dataset, cross-dataset, leave-one-dataset-out, and multi-dataset in-domain adaptation. To assess clinical relevance, we compare state-of-the-art motion encoders with a traditional gait-feature baseline, finding that encoders consistently outperform handcrafted features. Pretraining on CARE-PD reduces MPJPE (from 60.8mm to 7.5mm) and boosts PD severity macro-F1 by 17 percentage points, underscoring the value of clinically curated, diverse training data. CARE-PD and all benchmark code are released for non-commercial research at https://neurips2025.care-pd.ca/.

Shape Conditioned Human Motion Generation with Diffusion Model

Human motion synthesis is an important task in computer graphics and computer vision. While focusing on various conditioning signals such as text, action class, or audio to guide the generation process, most existing methods utilize skeleton-based pose representation, requiring additional skinning to produce renderable meshes. Given that human motion is a complex interplay of bones, joints, and muscles, considering solely the skeleton for generation may neglect their inherent interdependency, which can limit the variability and precision of the generated results. To address this issue, we propose a Shape-conditioned Motion Diffusion model (SMD), which enables the generation of motion sequences directly in mesh format, conditioned on a specified target mesh. In SMD, the input meshes are transformed into spectral coefficients using graph Laplacian, to efficiently represent meshes. Subsequently, we propose a Spectral-Temporal Autoencoder (STAE) to leverage cross-temporal dependencies within the spectral domain. Extensive experimental evaluations show that SMD not only produces vivid and realistic motions but also achieves competitive performance in text-to-motion and action-to-motion tasks when compared to state-of-the-art methods.

Enhancing Gait Video Analysis in Neurodegenerative Diseases by Knowledge Augmentation in Vision Language Model

We present a knowledge augmentation strategy for assessing the diagnostic groups and gait impairment from monocular gait videos. Based on a large-scale pre-trained Vision Language Model (VLM), our model learns and improves visual, textual, and numerical representations of patient gait videos, through a collective learning across three distinct modalities: gait videos, class-specific descriptions, and numerical gait parameters. Our specific contributions are two-fold: First, we adopt a knowledge-aware prompt tuning strategy to utilize the class-specific medical description in guiding the text prompt learning. Second, we integrate the paired gait parameters in the form of numerical texts to enhance the numeracy of the textual representation. Results demonstrate that our model not only significantly outperforms state-of-the-art (SOTA) in video-based classification tasks but also adeptly decodes the learned class-specific text features into natural language descriptions using the vocabulary of quantitative gait parameters. The code and the model will be made available at our project page.

4D Facial Expression Diffusion Model

Facial expression generation is one of the most challenging and long-sought aspects of character animation, with many interesting applications. The challenging task, traditionally having relied heavily on digital craftspersons, remains yet to be explored. In this paper, we introduce a generative framework for generating 3D facial expression sequences (i.e. 4D faces) that can be conditioned on different inputs to animate an arbitrary 3D face mesh. It is composed of two tasks: (1) Learning the generative model that is trained over a set of 3D landmark sequences, and (2) Generating 3D mesh sequences of an input facial mesh driven by the generated landmark sequences. The generative model is based on a Denoising Diffusion Probabilistic Model (DDPM), which has achieved remarkable success in generative tasks of other domains. While it can be trained unconditionally, its reverse process can still be conditioned by various condition signals. This allows us to efficiently develop several downstream tasks involving various conditional generation, by using expression labels, text, partial sequences, or simply a facial geometry. To obtain the full mesh deformation, we then develop a landmark-guided encoder-decoder to apply the geometrical deformation embedded in landmarks on a given facial mesh. Experiments show that our model has learned to generate realistic, quality expressions solely from the dataset of relatively small size, improving over the state-of-the-art methods. Videos and qualitative comparisons with other methods can be found at https://github.com/ZOUKaifeng/4DFM. Code and models will be made available upon acceptance.