Diffusion Posterior Proximal Sampling for Image Restoration

Diffusion models have demonstrated remarkable efficacy in generating high-quality samples. Existing diffusion-based image restoration algorithms exploit pre-trained diffusion models to leverage data priors, yet they still preserve elements inherited from the unconditional generation paradigm. These strategies initiate the denoising process with pure white noise and incorporate random noise at each generative step, leading to over-smoothed results. In this paper, we introduce a refined paradigm for diffusion-based image restoration. Specifically, we opt for a sample consistent with the measurement identity at each generative step, exploiting the sampling selection as an avenue for output stability and enhancement. Besides, we start the restoration process with an initialization combined with the measurement signal, providing supplementary information to better align the generative process. Extensive experimental results and analyses validate the effectiveness of our proposed approach across diverse image restoration tasks.

SemanticCAP: Chromatin Accessibility Prediction Enhanced by Features Learning from a Language Model

A large number of inorganic and organic compounds are able to bind DNA and form complexes, among which drug-related molecules are important. Chromatin accessibility changes not only directly affects drug-DNA interactions, but also promote or inhibit the expression of critical genes associated with drug resistance by affecting the DNA binding capacity of TFs and transcriptional regulators. However, Biological experimental techniques for measuring it are expensive and time consuming. In recent years, several kinds of computational methods have been proposed to identify accessible regions of the genome. Existing computational models mostly ignore the contextual information of bases in gene sequences. To address these issues, we proposed a new solution named SemanticCAP. It introduces a gene language model which models the context of gene sequences, thus being able to provide an effective representation of a certain site in gene sequences. Basically, we merge the features provided by the gene language model into our chromatin accessibility model. During the process, we designed some methods to make feature fusion smoother. Compared with other systems under public benchmarks, our model proved to have better performance.