Pan-cancer Histopathology WSI Pre-training with Position-aware Masked Autoencoder

Large-scale pre-training models have promoted the development of histopathology image analysis. However, existing self-supervised methods for histopathology images focus on learning patch features, while there is still a lack of available pre-training models for WSI-level feature learning. In this paper, we propose a novel self-supervised learning framework for pan-cancer WSI-level representation pre-training with the designed position-aware masked autoencoder (PAMA). Meanwhile, we propose the position-aware cross-attention (PACA) module with a kernel reorientation (KRO) strategy and an anchor dropout (AD) mechanism. The KRO strategy can capture the complete semantic structure and eliminate ambiguity in WSIs, and the AD contributes to enhancing the robustness and generalization of the model. We evaluated our method on 6 large-scale datasets from multiple organs for pan-cancer classification tasks. The results have demonstrated the effectiveness of PAMA in generalized and discriminative WSI representation learning and pan-cancer WSI pre-training. The proposed method was also compared with \R{7} WSI analysis methods. The experimental results have indicated that our proposed PAMA is superior to the state-of-the-art methods.The code and checkpoints are available at https://github.com/WkEEn/PAMA.

Multi-Microgrid Collaborative Optimization Scheduling Using an Improved Multi-Agent Soft Actor-Critic Algorithm

The implementation of a multi-microgrid (MMG) system with multiple renewable energy sources enables the facilitation of electricity trading. To tackle the energy management problem of a MMG system, which consists of multiple renewable energy microgrids belonging to different operating entities, this paper proposes a MMG collaborative optimization scheduling model based on a multi-agent centralized training distributed execution framework. To enhance the generalization ability of dealing with various uncertainties, we also propose an improved multi-agent soft actor-critic (MASAC) algorithm, which facilitates en-ergy transactions between multi-agents in MMG, and employs automated machine learning (AutoML) to optimize the MASAC hyperparameters to further improve the generalization of deep reinforcement learning (DRL). The test results demonstrate that the proposed method successfully achieves power complementarity between different entities, and reduces the MMG system operating cost. Additionally, the proposal significantly outperforms other state-of-the-art reinforcement learning algorithms with better economy and higher calculation efficiency.