IPGPhormer: Interpretable Pathology Graph-Transformer for Survival Analysis

Pathological images play an essential role in cancer prognosis, while survival analysis, which integrates computational techniques, can predict critical clinical events such as patient mortality or disease recurrence from whole-slide images (WSIs). Recent advancements in multiple instance learning have significantly improved the efficiency of survival analysis. However, existing methods often struggle to balance the modeling of long-range spatial relationships with local contextual dependencies and typically lack inherent interpretability, limiting their clinical utility. To address these challenges, we propose the Interpretable Pathology Graph-Transformer (IPGPhormer), a novel framework that captures the characteristics of the tumor microenvironment and models their spatial dependencies across the tissue. IPGPhormer uniquely provides interpretability at both tissue and cellular levels without requiring post-hoc manual annotations, enabling detailed analyses of individual WSIs and cross-cohort assessments. Comprehensive evaluations on four public benchmark datasets demonstrate that IPGPhormer outperforms state-of-the-art methods in both predictive accuracy and interpretability. In summary, our method, IPGPhormer, offers a promising tool for cancer prognosis assessment, paving the way for more reliable and interpretable decision-support systems in pathology. The code is publicly available at https://anonymous.4open.science/r/IPGPhormer-6EEB.

Self-Critique Guided Iterative Reasoning for Multi-hop Question Answering

Although large language models (LLMs) have demonstrated remarkable reasoning capabilities, they still face challenges in knowledge-intensive multi-hop reasoning. Recent work explores iterative retrieval to address complex problems. However, the lack of intermediate guidance often results in inaccurate retrieval and flawed intermediate reasoning, leading to incorrect reasoning. To address these, we propose Self-Critique Guided Iterative Reasoning (SiGIR), which uses self-critique feedback to guide the iterative reasoning process. Specifically, through end-to-end training, we enable the model to iteratively address complex problems via question decomposition. Additionally, the model is able to self-evaluate its intermediate reasoning steps. During iterative reasoning, the model engages in branching exploration and employs self-evaluation to guide the selection of promising reasoning trajectories. Extensive experiments on three multi-hop reasoning datasets demonstrate the effectiveness of our proposed method, surpassing the previous SOTA by $8.6\%$. Furthermore, our thorough analysis offers insights for future research. Our code, data, and models are available at Github: https://github.com/zchuz/SiGIR-MHQA.