Enhancing Clinically Significant Prostate Cancer Prediction in T2-weighted Images through Transfer Learning from Breast Cancer

In 2020, prostate cancer saw a staggering 1.4 million new cases, resulting in over 375,000 deaths. The accurate identification of clinically significant prostate cancer is crucial for delivering effective treatment to patients. Consequently, there has been a surge in research exploring the application of deep neural networks to predict clinical significance based on magnetic resonance images. However, these networks demand extensive datasets to attain optimal performance. Recently, transfer learning emerged as a technique that leverages acquired features from a domain with richer data to enhance the performance of a domain with limited data. In this paper, we investigate the improvement of clinically significant prostate cancer prediction in T2-weighted images through transfer learning from breast cancer. The results demonstrate a remarkable improvement of over 30% in leave-one-out cross-validation accuracy.

Improving Breast Cancer Grade Prediction with Multiparametric MRI Created Using Optimized Synthetic Correlated Diffusion Imaging

Breast cancer was diagnosed for over 7.8 million women between 2015 to 2020. Grading plays a vital role in breast cancer treatment planning. However, the current tumor grading method involves extracting tissue from patients, leading to stress, discomfort, and high medical costs. A recent paper leveraging volumetric deep radiomic features from synthetic correlated diffusion imaging (CDI$^s$) for breast cancer grade prediction showed immense promise for noninvasive methods for grading. Motivated by the impact of CDI$^s$ optimization for prostate cancer delineation, this paper examines using optimized CDI$^s$ to improve breast cancer grade prediction. We fuse the optimized CDI$^s$ signal with diffusion-weighted imaging (DWI) to create a multiparametric MRI for each patient. Using a larger patient cohort and training across all the layers of a pretrained MONAI model, we achieve a leave-one-out cross-validation accuracy of 95.79%, over 8% higher compared to that previously reported.

Using Multiparametric MRI with Optimized Synthetic Correlated Diffusion Imaging to Enhance Breast Cancer Pathologic Complete Response Prediction

In 2020, 685,000 deaths across the world were attributed to breast cancer, underscoring the critical need for innovative and effective breast cancer treatment. Neoadjuvant chemotherapy has recently gained popularity as a promising treatment strategy for breast cancer, attributed to its efficacy in shrinking large tumors and leading to pathologic complete response. However, the current process to recommend neoadjuvant chemotherapy relies on the subjective evaluation of medical experts which contain inherent biases and significant uncertainty. A recent study, utilizing volumetric deep radiomic features extracted from synthetic correlated diffusion imaging (CDI$^s$), demonstrated significant potential in noninvasive breast cancer pathologic complete response prediction. Inspired by the positive outcomes of optimizing CDI$^s$ for prostate cancer delineation, this research investigates the application of optimized CDI$^s$ to enhance breast cancer pathologic complete response prediction. Using multiparametric MRI that fuses optimized CDI$^s$ with diffusion-weighted imaging (DWI), we obtain a leave-one-out cross-validation accuracy of 93.28%, over 5.5% higher than that previously reported.

Optimizing Synthetic Correlated Diffusion Imaging for Breast Cancer Tumour Delineation

Breast cancer is a significant cause of death from cancer in women globally, highlighting the need for improved diagnostic imaging to enhance patient outcomes. Accurate tumour identification is essential for diagnosis, treatment, and monitoring, emphasizing the importance of advanced imaging technologies that provide detailed views of tumour characteristics and disease. Synthetic correlated diffusion imaging (CDI$^s$) is a recent method that has shown promise for prostate cancer delineation compared to current MRI images. In this paper, we explore tuning the coefficients in the computation of CDI$^s$ for breast cancer tumour delineation by maximizing the area under the receiver operating characteristic curve (AUC) using a Nelder-Mead simplex optimization strategy. We show that the best AUC is achieved by the CDI$^s$ - Optimized modality, outperforming the best gold-standard modality by 0.0044. Notably, the optimized CDI$^s$ modality also achieves AUC values over 0.02 higher than the Unoptimized CDI$^s$ value, demonstrating the importance of optimizing the CDI$^s$ exponents for the specific cancer application.

NutritionVerse-Direct: Exploring Deep Neural Networks for Multitask Nutrition Prediction from Food Images

Many aging individuals encounter challenges in effectively tracking their dietary intake, exacerbating their susceptibility to nutrition-related health complications. Self-reporting methods are often inaccurate and suffer from substantial bias; however, leveraging intelligent prediction methods can automate and enhance precision in this process. Recent work has explored using computer vision prediction systems to predict nutritional information from food images. Still, these methods are often tailored to specific situations, require other inputs in addition to a food image, or do not provide comprehensive nutritional information. This paper aims to enhance the efficacy of dietary intake estimation by leveraging various neural network architectures to directly predict a meal's nutritional content from its image. Through comprehensive experimentation and evaluation, we present NutritionVerse-Direct, a model utilizing a vision transformer base architecture with three fully connected layers that lead to five regression heads predicting calories (kcal), mass (g), protein (g), fat (g), and carbohydrates (g) present in a meal. NutritionVerse-Direct yields a combined mean average error score on the NutritionVerse-Real dataset of 412.6, an improvement of 25.5% over the Inception-ResNet model, demonstrating its potential for improving dietary intake estimation accuracy.

NutritionVerse-Synth: An Open Access Synthetically Generated 2D Food Scene Dataset for Dietary Intake Estimation

Manually tracking nutritional intake via food diaries is error-prone and burdensome. Automated computer vision techniques show promise for dietary monitoring but require large and diverse food image datasets. To address this need, we introduce NutritionVerse-Synth (NV-Synth), a large-scale synthetic food image dataset. NV-Synth contains 84,984 photorealistic meal images rendered from 7,082 dynamically plated 3D scenes. Each scene is captured from 12 viewpoints and includes perfect ground truth annotations such as RGB, depth, semantic, instance, and amodal segmentation masks, bounding boxes, and detailed nutritional information per food item. We demonstrate the diversity of NV-Synth across foods, compositions, viewpoints, and lighting. As the largest open-source synthetic food dataset, NV-Synth highlights the value of physics-based simulations for enabling scalable and controllable generation of diverse photorealistic meal images to overcome data limitations and drive advancements in automated dietary assessment using computer vision. In addition to the dataset, the source code for our data generation framework is also made publicly available at https://saeejithnair.github.io/nvsynth.

FoodFusion: A Latent Diffusion Model for Realistic Food Image Generation

Current state-of-the-art image generation models such as Latent Diffusion Models (LDMs) have demonstrated the capacity to produce visually striking food-related images. However, these generated images often exhibit an artistic or surreal quality that diverges from the authenticity of real-world food representations. This inadequacy renders them impractical for applications requiring realistic food imagery, such as training models for image-based dietary assessment. To address these limitations, we introduce FoodFusion, a Latent Diffusion model engineered specifically for the faithful synthesis of realistic food images from textual descriptions. The development of the FoodFusion model involves harnessing an extensive array of open-source food datasets, resulting in over 300,000 curated image-caption pairs. Additionally, we propose and employ two distinct data cleaning methodologies to ensure that the resulting image-text pairs maintain both realism and accuracy. The FoodFusion model, thus trained, demonstrates a remarkable ability to generate food images that exhibit a significant improvement in terms of both realism and diversity over the publicly available image generation models. We openly share the dataset and fine-tuned models to support advancements in this critical field of food image synthesis at https://bit.ly/genai4good.

Cancer-Net PCa-Gen: Synthesis of Realistic Prostate Diffusion Weighted Imaging Data via Anatomic-Conditional Controlled Latent Diffusion

In Canada, prostate cancer is the most common form of cancer in men and accounted for 20% of new cancer cases for this demographic in 2022. Due to recent successes in leveraging machine learning for clinical decision support, there has been significant interest in the development of deep neural networks for prostate cancer diagnosis, prognosis, and treatment planning using diffusion weighted imaging (DWI) data. A major challenge hindering widespread adoption in clinical use is poor generalization of such networks due to scarcity of large-scale, diverse, balanced prostate imaging datasets for training such networks. In this study, we explore the efficacy of latent diffusion for generating realistic prostate DWI data through the introduction of an anatomic-conditional controlled latent diffusion strategy. To the best of the authors' knowledge, this is the first study to leverage conditioning for synthesis of prostate cancer imaging. Experimental results show that the proposed strategy, which we call Cancer-Net PCa-Gen, enhances synthesis of diverse prostate images through controllable tumour locations and better anatomical and textural fidelity. These crucial features make it well-suited for augmenting real patient data, enabling neural networks to be trained on a more diverse and comprehensive data distribution. The Cancer-Net PCa-Gen framework and sample images have been made publicly available at https://www.kaggle.com/datasets/deetsadi/cancer-net-pca-gen-dataset as a part of a global open-source initiative dedicated to accelerating advancement in machine learning to aid clinicians in the fight against cancer.

COVIDx CXR-4: An Expanded Multi-Institutional Open-Source Benchmark Dataset for Chest X-ray Image-Based Computer-Aided COVID-19 Diagnostics

The global ramifications of the COVID-19 pandemic remain significant, exerting persistent pressure on nations even three years after its initial outbreak. Deep learning models have shown promise in improving COVID-19 diagnostics but require diverse and larger-scale datasets to improve performance. In this paper, we introduce COVIDx CXR-4, an expanded multi-institutional open-source benchmark dataset for chest X-ray image-based computer-aided COVID-19 diagnostics. COVIDx CXR-4 expands significantly on the previous COVIDx CXR-3 dataset by increasing the total patient cohort size by greater than 2.66 times, resulting in 84,818 images from 45,342 patients across multiple institutions. We provide extensive analysis on the diversity of the patient demographic, imaging metadata, and disease distributions to highlight potential dataset biases. To the best of the authors' knowledge, COVIDx CXR-4 is the largest and most diverse open-source COVID-19 CXR dataset and is made publicly available as part of an open initiative to advance research to aid clinicians against the COVID-19 disease.

Cancer-Net PCa-Data: An Open-Source Benchmark Dataset for Prostate Cancer Clinical Decision Support using Synthetic Correlated Diffusion Imaging Data

The recent introduction of synthetic correlated diffusion (CDI$^s$) imaging has demonstrated significant potential in the realm of clinical decision support for prostate cancer (PCa). CDI$^s$ is a new form of magnetic resonance imaging (MRI) designed to characterize tissue characteristics through the joint correlation of diffusion signal attenuation across different Brownian motion sensitivities. Despite the performance improvement, the CDI$^s$ data for PCa has not been previously made publicly available. In our commitment to advance research efforts for PCa, we introduce Cancer-Net PCa-Data, an open-source benchmark dataset of volumetric CDI$^s$ imaging data of PCa patients. Cancer-Net PCa-Data consists of CDI$^s$ volumetric images from a patient cohort of 200 patient cases, along with full annotations (gland masks, tumor masks, and PCa diagnosis for each tumor). We also analyze the demographic and label region diversity of Cancer-Net PCa-Data for potential biases. Cancer-Net PCa-Data is the first-ever public dataset of CDI$^s$ imaging data for PCa, and is a part of the global open-source initiative dedicated to advancement in machine learning and imaging research to aid clinicians in the global fight against cancer.