A Hybrid Instance-based Transfer Learning Method

In recent years, supervised machine learning models have demonstrated tremendous success in a variety of application domains. Despite the promising results, these successful models are data hungry and their performance relies heavily on the size of training data. However, in many healthcare applications it is difficult to collect sufficiently large training datasets. Transfer learning can help overcome this issue by transferring the knowledge from readily available datasets (source) to a new dataset (target). In this work, we propose a hybrid instance-based transfer learning method that outperforms a set of baselines including state-of-the-art instance-based transfer learning approaches. Our method uses a probabilistic weighting strategy to fuse information from the source domain to the model learned in the target domain. Our method is generic, applicable to multiple source domains, and robust with respect to negative transfer. We demonstrate the effectiveness of our approach through extensive experiments for two different applications.

Learning to Unlearn: Building Immunity to Dataset Bias in Medical Imaging Studies

Medical imaging machine learning algorithms are usually evaluated on a single dataset. Although training and testing are performed on different subsets of the dataset, models built on one study show limited capability to generalize to other studies. While database bias has been recognized as a serious problem in the computer vision community, it has remained largely unnoticed in medical imaging research. Transfer learning thus remains confined to the re-use of feature representations requiring re-training on the new dataset. As a result, machine learning models do not generalize even when trained on imaging datasets that were captured to study the same variable of interest. The ability to transfer knowledge gleaned from one study to another, without the need for re-training, if possible, would provide reassurance that the models are learning knowledge fundamental to the problem under study instead of latching onto the idiosyncracies of a dataset. In this paper, we situate the problem of dataset bias in the context of medical imaging studies. We show empirical evidence that such a problem exists in medical datasets. We then present a framework to unlearn study membership as a means to handle the problem of database bias. Our main idea is to take the data from the original feature space to an intermediate space where the data points are indistinguishable in terms of which study they come from, while maintaining the recognition capability with respect to the variable of interest. This will promote models which learn the more general properties of the etiology under study instead of aligning to dataset-specific peculiarities. Essentially, our proposed model learns to unlearn the dataset bias.

Subspace Selection to Suppress Confounding Source Domain Information in AAM Transfer Learning

Active appearance models (AAMs) are a class of generative models that have seen tremendous success in face analysis. However, model learning depends on the availability of detailed annotation of canonical landmark points. As a result, when accurate AAM fitting is required on a different set of variations (expression, pose, identity), a new dataset is collected and annotated. To overcome the need for time consuming data collection and annotation, transfer learning approaches have received recent attention. The goal is to transfer knowledge from previously available datasets (source) to a new dataset (target). We propose a subspace transfer learning method, in which we select a subspace from the source that best describes the target space. We propose a metric to compute the directional similarity between the source eigenvectors and the target subspace. We show an equivalence between this metric and the variance of target data when projected onto source eigenvectors. Using this equivalence, we select a subset of source principal directions that capture the variance in target data. To define our model, we augment the selected source subspace with the target subspace learned from a handful of target examples. In experiments done on six publicly available datasets, we show that our approach outperforms the state of the art in terms of the RMS fitting error as well as the percentage of test examples for which AAM fitting converges to the ground truth.

Vision-Based Assessment of Parkinsonism and Levodopa-Induced Dyskinesia with Deep Learning Pose Estimation

Objective: To apply deep learning pose estimation algorithms for vision-based assessment of parkinsonism and levodopa-induced dyskinesia (LID). Methods: Nine participants with Parkinson's disease (PD) and LID completed a levodopa infusion protocol, where symptoms were assessed at regular intervals using the Unified Dyskinesia Rating Scale (UDysRS) and Unified Parkinson's Disease Rating Scale (UPDRS). A state-of-the-art deep learning pose estimation method was used to extract movement trajectories from videos of PD assessments. Features of the movement trajectories were used to detect and estimate the severity of parkinsonism and LID using random forest. Communication and drinking tasks were used to assess LID, while leg agility and toe tapping tasks were used to assess parkinsonism. Feature sets from tasks were also combined to predict total UDysRS and UPDRS Part III scores. Results: For LID, the communication task yielded the best results for dyskinesia (severity estimation: r = 0.661, detection: AUC = 0.930). For parkinsonism, leg agility had better results for severity estimation (r = 0.618), while toe tapping was better for detection (AUC = 0.773). UDysRS and UPDRS Part III scores were predicted with r = 0.741 and 0.530, respectively. Conclusion: This paper presents the first application of deep learning for vision-based assessment of parkinsonism and LID and demonstrates promising performance for the future translation of deep learning to PD clinical practices. Significance: The proposed system provides insight into the potential of computer vision and deep learning for clinical application in PD.

Detecting Unseen Falls from Wearable Devices using Channel-wise Ensemble of Autoencoders

A fall is an abnormal activity that occurs rarely, so it is hard to collect real data for falls. It is, therefore, difficult to use supervised learning methods to automatically detect falls. Another challenge in using machine learning methods to automatically detect falls is the choice of engineered features. In this paper, we propose to use an ensemble of autoencoders to extract features from different channels of wearable sensor data trained only on normal activities. We show that the traditional approach of choosing a threshold as the maximum of the reconstruction error on the training normal data is not the right way to identify unseen falls. We propose two methods for automatic tightening of reconstruction error from only the normal activities for better identification of unseen falls. We present our results on two activity recognition datasets and show the efficacy of our proposed method against traditional autoencoder models and two standard one-class classification methods.

Video Analysis of "YouTube Funnies" to Aid the Study of Human Gait and Falls - Preliminary Results and Proof of Concept

Because falls are funny, YouTube and other video sharing sites contain a large repository of real-life falls. We propose extracting gait and balance information from these videos to help us better understand some of the factors that contribute to falls. Proof-of-concept is explored in a single video containing multiple (n=14) falls/non-falls in the presence of an unexpected obstacle. The analysis explores: computing spatiotemporal parameters of gait in a video captured from an arbitrary viewpoint; the relationship between parameters of gait from the last few steps before the obstacle and falling vs. not falling; and the predictive capacity of a multivariate model in predicting a fall in the presence of an unexpected obstacle. Homography transformations correct the perspective projection distortion and allow for the consistent tracking of gait parameters as an individual walks in an arbitrary direction in the scene. A synthetic top view allows for computing the average stride length and a synthetic side view allows for measuring up and down motions of the head. In leave-one-out cross-validation, we were able to correctly predict whether a person would fall or not in 11 out of the 14 cases (78.6%), just by looking at the average stride length and the range of vertical head motion during the 1-4 most recent steps prior to reaching the obstacle.

Difference of Normals as a Multi-Scale Operator in Unorganized Point Clouds

A novel multi-scale operator for unorganized 3D point clouds is introduced. The Difference of Normals (DoN) provides a computationally efficient, multi-scale approach to processing large unorganized 3D point clouds. The application of DoN in the multi-scale filtering of two different real-world outdoor urban LIDAR scene datasets is quantitatively and qualitatively demonstrated. In both datasets the DoN operator is shown to segment large 3D point clouds into scale-salient clusters, such as cars, people, and lamp posts towards applications in semi-automatic annotation, and as a pre-processing step in automatic object recognition. The application of the operator to segmentation is evaluated on a large public dataset of outdoor LIDAR scenes with ground truth annotations.