Clinical Applications of Plantar Pressure Measurement

Plantar pressure measurements can provide valuable insight into various health characteristics in patients. In this study, we describe different plantar pressure devices available on the market and their clinical relevance. Current devices are either platform-based or wearable and consist of a variety of sensor technologies: resistive, capacitive, piezoelectric, and optical. The measurements collected from any of these sensors can be utilized for a range of clinical applications including patients with diabetes, trauma, deformity and cerebral palsy, stroke, cervical myelopathy, ankle instability, sports injuries, and Parkinsons disease. However, the proper technology should be selected based on the clinical need and the type of tests being performed on the device. In this review we provide the reader with a simple overview of the existing technologies their advantages and disadvantages and provide application examples for each. Moreover, we suggest new areas in orthopaedic that plantar pressure mapping technology can be utilized for increased quality of care.

Scaling Up Models and Data with $\texttt{t5x}$ and $\texttt{seqio}$

Recent neural network-based language models have benefited greatly from scaling up the size of training datasets and the number of parameters in the models themselves. Scaling can be complicated due to various factors including the need to distribute computation on supercomputer clusters (e.g., TPUs), prevent bottlenecks when infeeding data, and ensure reproducible results. In this work, we present two software libraries that ease these issues: $\texttt{t5x}$ simplifies the process of building and training large language models at scale while maintaining ease of use, and $\texttt{seqio}$ provides a task-based API for simple creation of fast and reproducible training data and evaluation pipelines. These open-source libraries have been used to train models with hundreds of billions of parameters on datasets with multiple terabytes of training data. Along with the libraries, we release configurations and instructions for T5-like encoder-decoder models as well as GPT-like decoder-only architectures. $\texttt{t5x}$ and $\texttt{seqio}$ are open source and available at https://github.com/google-research/t5x and https://github.com/google/seqio, respectively.

Spatial Graph Attention and Curiosity-driven Policy for Antiviral Drug Discovery

We developed Distilled Graph Attention Policy Networks (DGAPNs), a curiosity-driven reinforcement learning model to generate novel graph-structured chemical representations that optimize user-defined objectives by efficiently navigating a physically constrained domain. The framework is examined on the task of generating molecules that are designed to bind, noncovalently, to functional sites of SARS-CoV-2 proteins. We present a spatial Graph Attention Network (sGAT) that leverages self-attention over both node and edge attributes as well as encoding spatial structure -- this capability is of considerable interest in areas such as molecular and synthetic biology and drug discovery. An attentional policy network is then introduced to learn decision rules for a dynamic, fragment-based chemical environment, and state-of-the-art policy gradient techniques are employed to train the network with enhanced stability. Exploration is efficiently encouraged by incorporating innovation reward bonuses learned and proposed by random network distillation. In experiments, our framework achieved outstanding results compared to state-of-the-art algorithms, while increasing the diversity of proposed molecules and reducing the complexity of paths to chemical synthesis.