Machine Learning Transferability for Malware Detection

Malware continues to be a predominant operational risk for organizations, especially when obfuscation techniques are used to evade detection. Despite the ongoing efforts in the development of Machine Learning (ML) detection approaches, there is still a lack of feature compatibility in public datasets. This limits generalization when facing distribution shifts, as well as transferability to different datasets. This study evaluates the suitability of different data preprocessing approaches for the detection of Portable Executable (PE) files with ML models. The preprocessing pipeline unifies EMBERv2 (2,381-dim) features datasets, trains paired models under two training setups: EMBER + BODMAS and EMBER + BODMAS + ERMDS. Regarding model evaluation, both EMBER + BODMAS and EMBER + BODMAS + ERMDS models are tested against TRITIUM, INFERNO and SOREL-20M. ERMDS is also used for testing for the EMBER + BODMAS setup.

Evaluating Interactive 2D Visualization as a Sample Selection Strategy for Biomedical Time-Series Data Annotation

Reliable machine-learning models in biomedical settings depend on accurate labels, yet annotating biomedical time-series data remains challenging. Algorithmic sample selection may support annotation, but evidence from studies involving real human annotators is scarce. Consequently, we compare three sample selection methods for annotation: random sampling (RND), farthest-first traversal (FAFT), and a graphical user interface-based method enabling exploration of complementary 2D visualizations (2DVs) of high-dimensional data. We evaluated the methods across four classification tasks in infant motility assessment (IMA) and speech emotion recognition (SER). Twelve annotators, categorized as experts or non-experts, performed data annotation under a limited annotation budget, and post-annotation experiments were conducted to evaluate the sampling methods. Across all classification tasks, 2DV performed best when aggregating labels across annotators. In IMA, 2DV most effectively captured rare classes, but also exhibited greater annotator-to-annotator label distribution variability resulting from the limited annotation budget, decreasing classification performance when models were trained on individual annotators' labels; in these cases, FAFT excelled. For SER, 2DV outperformed the other methods among expert annotators and matched their performance for non-experts in the individual-annotator setting. A failure risk analysis revealed that RND was the safest choice when annotator count or annotator expertise was uncertain, whereas 2DV had the highest risk due to its greater label distribution variability. Furthermore, post-experiment interviews indicated that 2DV made the annotation task more interesting and enjoyable. Overall, 2DV-based sampling appears promising for biomedical time-series data annotation, particularly when the annotation budget is not highly constrained.

EnTaCs: Analyzing the Relationship Between Sentiment and Language Choice in English-Tamil Code-Switching

This paper investigates the relationship between utterance sentiment and language choice in English-Tamil code-switched text, using methods from machine learning and statistical modelling. We apply a fine-tuned XLM-RoBERTa model for token-level language identification on 35,650 romanized YouTube comments from the DravidianCodeMix dataset, producing per-utterance measurements of English proportion and language switch frequency. Linear regression analysis reveals that positive utterances exhibit significantly greater English proportion (34.3%) than negative utterances (24.8%), and mixed-sentiment utterances show the highest language switch frequency when controlling for utterance length. These findings support the hypothesis that emotional content demonstrably influences language choice in multilingual code-switching settings, due to socio-linguistic associations of prestige and identity with embedded and matrix languages.

AMALIA Technical Report: A Fully Open Source Large Language Model for European Portuguese

Despite rapid progress in open large language models (LLMs), European Portuguese (pt-PT) remains underrepresented in both training data and native evaluation, with machine-translated benchmarks likely missing the variant's linguistic and cultural nuances. We introduce AMALIA, a fully open LLM that prioritizes pt-PT by using more high-quality pt-PT data during both the mid- and post-training stages. To evaluate pt-PT more faithfully, we release a suite of pt-PT benchmarks that includes translated standard tasks and four new datasets targeting pt-PT generation, linguistic competence, and pt-PT/pt-BR bias. Experiments show that AMALIA matches strong baselines on translated benchmarks while substantially improving performance on pt-PT-specific evaluations, supporting the case for targeted training and native benchmarking for European Portuguese.

Targeted learning of heterogeneous treatment effect curves for right censored or left truncated time-to-event data

In recent years, there has been growing interest in causal machine learning estimators for quantifying subject-specific effects of a binary treatment on time-to-event outcomes. Estimation approaches have been proposed which attenuate the inherent regularisation bias in machine learning predictions, with each of these estimators addressing measured confounding, right censoring, and in some cases, left truncation. However, the existing approaches are found to exhibit suboptimal finite-sample performance, with none of the existing estimators fully leveraging the temporal structure of the data, yielding non-smooth treatment effects over time. We address these limitations by introducing surv-iTMLE, a targeted learning procedure for estimating the difference in the conditional survival probabilities under two treatments. Unlike existing estimators, surv-iTMLE accommodates both left truncation and right censoring while enforcing smoothness and boundedness of the estimated treatment effect curve over time. Through extensive simulation studies under both right censoring and left truncation scenarios, we demonstrate that surv-iTMLE outperforms existing methods in terms of bias and smoothness of time-varying effect estimates in finite samples. We then illustrate surv-iTMLE's practical utility by exploring heterogeneity in the effects of immunotherapy on survival among non-small cell lung cancer (NSCLC) patients, revealing clinically meaningful temporal patterns that existing estimators may obscure.

Shapley meets Rawls: an integrated framework for measuring and explaining unfairness

Explainability and fairness have mainly been considered separately, with recent exceptions trying the explain the sources of unfairness. This paper shows that the Shapley value can be used to both define and explain unfairness, under standard group fairness criteria. This offers an integrated framework to estimate and derive inference on unfairness as-well-as the features that contribute to it. Our framework can also be extended from Shapley values to the family of Efficient-Symmetric-Linear (ESL) values, some of which offer more robust definitions of fairness, and shorter computation times. An illustration is run on the Census Income dataset from the UCI Machine Learning Repository. Our approach shows that ``Age", ``Number of hours" and ``Marital status" generate gender unfairness, using shorter computation time than traditional Bootstrap tests.

Fair Data Pre-Processing with Imperfect Attribute Space

Fair data pre-processing is a widely used strategy for mitigating bias in machine learning. A promising line of research focuses on calibrating datasets to satisfy a designed fairness policy so that sensitive attributes influence outcomes only through clearly specified legitimate causal pathways. While effective on clean and information-rich data, these methods often break down in real-world scenarios with imperfect attribute spaces, where decision-relevant factors may be deemed unusable or even missing. To address this gap, we propose LatentPre, a novel framework that enables principled and robust fair data processing in practical settings. Instead of relying solely on observed attributes, LatentPre augments the fairness policy with latent attributes that capture essential but subtle signals, enabling the framework to operate as if the attribute space were perfect. These latent attributes are strategically introduced to guarantee identifiability and are estimated using a tailored expectation-maximization paradigm. The raw data is then carefully refined to conform to this latent-augmented policy, effectively removing biased patterns while preserving justifiable ones. Extensive experiments demonstrate that LatentPre consistently achieves strong fairness-utility trade-offs across diverse scenarios, advancing practical fairness-aware data management.

PRISMA: Toward a Normative Information Infrastructure for Responsible Pharmaceutical Knowledge Management

Most existing approaches to AI in pharmacy collapse three epistemologically distinct operations into a single technical layer: document preservation, semantic interpretation, and contextual presentation. This conflation is a root cause of recurring fragilities including loss of provenance, interpretive opacity, alert fatigue, and erosion of accountability. This paper proposes the PATOS--Lector--PRISMA (PLP) infrastructure as a normative information architecture for responsible pharmaceutical knowledge management. PATOS preserves regulatory documents with explicit versioning and provenance; Lector implements machine-assisted reading with human curation, producing typed assertions anchored to primary sources; PRISMA delivers contextual presentation through the RPDA framework (Regulatory, Prescription, Dispensing, Administration), refracting the same informational core into distinct professional views. The architecture introduces the Evidence Pack as a formal unit of accountable assertion (versioned, traceable, epistemically bounded, and curatorially validated), with assertions typified by illocutionary force. A worked example traces dipyrone monohydrate across all three layers using real system data. Developed and validated in Brazil's regulatory context, the architecture is grounded in an operational implementation comprising over 16,000 official documents and 38 curated Evidence Packs spanning five reference medications. The proposal is demonstrated as complementary to operational decision support systems, providing infrastructural conditions that current systems lack: documentary anchoring, interpretive transparency, and institutional accountability.

Improving Risk Stratification in Hypertrophic Cardiomyopathy: A Novel Score Combining Echocardiography, Clinical, and Medication Data

Hypertrophic cardiomyopathy (HCM) requires accurate risk stratification to inform decisions regarding ICD therapy and follow-up management. Current established models, such as the European Society of Cardiology (ESC) score, exhibit moderate discriminative performance. This study develops a robust, explainable machine learning (ML) risk score leveraging routinely collected echocardiographic, clinical, and medication data, typically contained within Electronic Health Records (EHRs), to predict a 5-year composite cardiovascular outcome in HCM patients. The model was trained and internally validated using a large cohort (N=1,201) from the SHARE registry (Florence Hospital) and externally validated on an independent cohort (N=382) from Rennes Hospital. The final Random Forest ensemble model achieved a high internal Area Under the Curve (AUC) of 0.85 +- 0.02, significantly outperforming the ESC score (0.56 +- 0.03). Critically, survival curve analysis on the external validation set showed superior risk separation for the ML score (Log-rank p = 8.62 x 10^(-4) compared to the ESC score (p = 0.0559). Furthermore, longitudinal analyses demonstrate that the proposed risk score remains stable over time in event-free patients. The model high interpretability and its capacity for longitudinal risk monitoring represent promising tools for the personalized clinical management of HCM.

Semi-Automated Knowledge Engineering and Process Mapping for Total Airport Management

Documentation of airport operations is inherently complex due to extensive technical terminology, rigorous regulations, proprietary regional information, and fragmented communication across multiple stakeholders. The resulting data silos and semantic inconsistencies present a significant impediment to the Total Airport Management (TAM) initiative. This paper presents a methodological framework for constructing a domain-grounded, machine-readable Knowledge Graph (KG) through a dual-stage fusion of symbolic Knowledge Engineering (KE) and generative Large Language Models (LLMs). The framework employs a scaffolded fusion strategy in which expert-curated KE structures guide LLM prompts to facilitate the discovery of semantically aligned knowledge triples. We evaluate this methodology on the Google LangExtract library and investigate the impact of context window utilization by comparing localized segment-based inference with document-level processing. Contrary to prior empirical observations of long-context degradation in LLMs, document-level processing improves the recovery of non-linear procedural dependencies. To ensure the high-fidelity provenance required in airport operations, the proposed framework fuses a probabilistic model for discovery and a deterministic algorithm for anchoring every extraction to its ground source. This ensures absolute traceability and verifiability, bridging the gap between "black-box" generative outputs and the transparency required for operational tooling. Finally, we introduce an automated framework that operationalizes this pipeline to synthesize complex operational workflows from unstructured textual corpora.