Large-scale homepage recommendations face critical challenges from pseudo-negative samples caused by exposure bias, where non-clicks may indicate inattention rather than disinterest. Existing work lacks thorough analysis of invalid exposures and typically addresses isolated aspects (e.g., sampling strategies), overlooking the critical impact of pseudo-positive samples - such as homepage clicks merely to visit marketing portals. We propose a unified framework for large-scale homepage recommendation sampling and debiasing. Our framework consists of two key components: (1) a user intent-aware negative sampling module to filter invalid exposure samples, and (2) an intent-driven dual-debiasing module that jointly corrects exposure bias and click bias. Extensive online experiments on Taobao demonstrate the efficacy of our framework, achieving significant improvements in user click-through rates (UCTR) by 35.4\% and 14.5\% in two variants of the marketing block on the Taobao homepage, Baiyibutie and Taobaomiaosha.