Simulation-to-Real First-Break Segmentation for Efficient Inversion in Musculoskeletal Ultrasound Tomography

Full-waveform inversion (FWI) is a promising strategy for quantitative musculoskeletal ultrasound computed tomography (USCT), but bone-related scattering, attenuation, and signal degradation make it highly sensitive to the accuracy of the initial acoustic-property distributions and prone to cycle skipping. First-arrival traveltimes provide important kinematic information for initial-model construction, yet conventional trace-wise picking is unreliable when arrivals are weak, spatially heterogeneous, or buried in system noise. We propose a learning-assisted reconstruction pipeline that combines segmentation-based first-arrival extraction with hybrid full-waveform inversion (HFWI), which incorporates Rytov-approximation-based traveltime information together with waveform fitting during the early inversion stage. A lightweight 2D U-Net treats the first-arrival trajectory across receiver channels as a first-break segmentation target and exploits its spatial continuity rather than processing each trace independently. To address both limited manual annotations and the simulation-to-real gap, the network is pretrained on task-specific simulations augmented with real system-noise recordings, followed by stage-wise training with progressively increased signal degradation and decoder-only fine-tuning using limited weakly labeled experimental data. The method is evaluated on in vitro phantom, ex vivo bovine-limb, and in vivo human-thigh datasets. Compared with conventional STA/LTA picking, the proposed network yields more spatially coherent first-arrival trajectories, lower mean extraction errors, and processes a full-matrix-capture dataset within seconds. When integrated into HFWI, the extracted arrivals improve initial-model construction and lead to stable subsequent FWI reconstructions, including challenging cases with estimated local first-arrival SNRs below 3 dB.