This article presents and discusses challenges and solutions for practical issues in bistatic integrated sensing and communication (ISAC) in 6G networks. Considering orthogonal frequency-division multiplexing as the adopted waveform, a discussion on system design aiming to achieve both a desired sensing key performance indicators and limit the impact of hardware impairments is presented. In addition, signal processing techniques to enable over-the-air synchronization and generation of periodograms with range, Doppler shift, and angular information are discussed. Simulation results are then presented for a cellular-based ISAC scenario considering system parameterization compliant to current 5G and, finally, a discussion on open challenges for future deployments is presented.