Longitudinal 3D Foundation Modeling for Neoadjuvant Breast Cancer Response Prediction from Serial DCE-MRI

Pathologic complete response (pCR) is an important endpoint in neoadjuvant chemotherapy (NAC) for breast cancer, and predicting pCR from imaging during treatment could support treatment response assessment. Many existing imaging-based approaches rely on a single static timepoint, which fails to capture changes that occur during treatment. In this work, we present a longitudinal framework that combines a frozen 3D foundation encoder (Pillar-0) with our Temporal Dynamics Network (TDN) to predict treatment response from serial Dynamic Contrast-Enhanced (DCE) MRI acquired across four clinical timepoints from pre-treatment to pre-surgery. The TDN combines time-aware volumetric embeddings with clinical and treatment data to predict pCR. Evaluated on 982 patients from the combined I-SPY2 and ACRIN-6698 cohort, the proposed model achieves strong performance across all reported metrics when longitudinal 3D imaging is fused with clinical data (test AUROC: 73.6%, balanced accuracy: 69.1%). While clinical variables provide the strongest individual predictive signal, longitudinal 3D imaging contributes complementary information when fused with clinical data, improving pCR prediction. Our source code is available at: https://github.com/omarftt/longitudinal_temporal_pillar.

Sky2Ground: A Benchmark for Site Modeling under Varying Altitude

We introduce Sky2Ground, a three-view dataset designed for varying altitude camera localization, correspondence learning, and reconstruction. The dataset combines structured synthetic imagery with real, in-the-wild images, providing both controlled multi-view geometry and realistic scene noise. Each of the 51 sites contains thousands of satellite, aerial, and ground images spanning wide altitude ranges and nearly orthogonal viewing angles, enabling rigorous evaluation across global-to-local contexts. We benchmark state of the art pose estimation models, including MASt3R, DUSt3R, Map Anything, and VGGT, and observe that the use of satellite imagery often degrades performance, highlighting the challenges under large altitude variations. We also examine reconstruction methods, highlighting the challenges introduced by sparse geometric overlap, varying perspectives, and the use of real imagery, which often introduces noise and reduces rendering quality. To address some of these challenges, we propose SkyNet, a model which enhances cross-view consistency when incorporating satellite imagery with a curriculum-based training strategy to progressively incorporate more satellite views. SkyNet significantly strengthens multi-view alignment and outperforms existing methods by 9.6% on RRA@5 and 18.1% on RTA@5 in terms of absolute performance. Sky2Ground and SkyNet together establish a comprehensive testbed and baseline for advancing large-scale, multi-altitude 3D perception and generalizable camera localization. Code and models will be released publicly for future research.