EarlyDx: An Admission-Anchored Benchmark for Open-Ended Generation of Evidence-Supported ED-Encounter Diagnoses

Clinical diagnosis at hospital admission must be made rapidly from limited, incomplete evidence. Existing diagnosis-prediction benchmarks are poorly suited to this setting: they restrict prediction to closed code sets, exclude free-text notes, and supervise with discharge diagnoses that incorporate the full inpatient course. We introduce EarlyDx, a large-scale benchmark for open-ended early diagnosis, built from 154,834 emergency department encounters in MIMIC-IV. Each encounter is restricted to records available at admission time $t_0$ and supervised by the diagnoses recorded during the ED encounter rather than at discharge. An LLM auditor further verifies every free-text label as supported, partially supported, or unsupported by that evidence; the primary evaluation scores only fully supported labels. Under a semantic LLM-as-judge protocol, no evaluated system --- frontier general, medical-specialized, or in-domain post-trained --- synthesizes admission-time evidence reliably. Zero-shot models score largely by extraction, recovering only 3-31% of diagnoses that must be inferred rather than read from the record; post-training raises inference-dependent recall to 56%, but a sizeable margin remains, and on time-critical conditions no system attains a clinician's balance of sensitivity and precision. We release the full construction and evaluation pipeline at here.

From Triggers to Emotions: A CPM-Grounded Appraisal Multi-Agent for Dynamic Emotional Evolution in Persona-Based Dialogue

Large Language Models (LLMs) have substantially advanced persona-based dialogue agents for emotion-sensitive role simulation in healthcare, education, counseling, customer service, and interactive storytelling. However, two related lines of work leave a key gap. Persona-based dialogue systems often encode emotions as static traits or surface-level stylistic cues, and affective dialogue research has largely focused on empathetic response generation toward users rather than modeling the agent persona's own evolving emotional state. As a result, trigger-driven emotional evolution within a character remains underexplored. To address this limitation, we draw inspiration from the Component Process Model (CPM), a psychological theory that views emotion as a dynamic process shaped by the appraisal of external events. We propose CPM-MultiAgent, a CPM-grounded emotion evolution multi-agent framework for supporting emotional changes in persona-based dialogue. Instead of treating a character's emotion as a fixed attribute, CPM-MultiAgent represents it as a latent state that is continuously reshaped by dialogue triggers. Through affective trigger extraction, CPM-based collaborative appraisal, and emotion state updating, the framework enables more emotionally consistent role simulation in multi-turn interactions.Experiments with baseline comparisons, ablation studies, human evaluation, and case analyses demonstrate that CPM-MultiAgent effectively models dynamic emotional evolution in emotionally sensitive role-simulation settings.

GRNN:Recurrent Neural Network based on Ghost Features for Video Super-Resolution

Modern video super-resolution (VSR) systems based on convolutional neural networks (CNNs) require huge computational costs. The problem of feature redundancy is present in most models in many domains, but is rarely discussed in VSR. We experimentally observe that many features in VSR models are also similar to each other, so we propose to use "Ghost features" to reduce this redundancy. We also analyze the so-called "gradient disappearance" phenomenon generated by the conventional recurrent convolutional network (RNN) model, and combine the Ghost module with RNN to complete the modeling on time series. The current frame is used as input to the model together with the next frame, the output of the previous frame and the hidden state. Extensive experiments on several benchmark models and datasets show that the PSNR and SSIM of our proposed modality are improved to some extent. Some texture details in the video are also better preserved.

AMPCliff: quantitative definition and benchmarking of activity cliffs in antimicrobial peptides

Activity cliff (AC) is a phenomenon that a pair of similar molecules differ by a small structural alternation but exhibit a large difference in their biochemical activities. The AC of small molecules has been extensively investigated but limited knowledge is accumulated about the AC phenomenon in peptides with canonical amino acids. This study introduces a quantitative definition and benchmarking framework AMPCliff for the AC phenomenon in antimicrobial peptides (AMPs) composed by canonical amino acids. A comprehensive analysis of the existing AMP dataset reveals a significant prevalence of AC within AMPs. AMPCliff quantifies the activities of AMPs by the metric minimum inhibitory concentration (MIC), and defines 0.9 as the minimum threshold for the normalized BLOSUM62 similarity score between a pair of aligned peptides with at least two-fold MIC changes. This study establishes a benchmark dataset of paired AMPs in Staphylococcus aureus from the publicly available AMP dataset GRAMPA, and conducts a rigorous procedure to evaluate various AMP AC prediction models, including nine machine learning, four deep learning algorithms, four masked language models, and four generative language models. Our analysis reveals that these models are capable of detecting AMP AC events and the pre-trained protein language ESM2 model demonstrates superior performance across the evaluations. The predictive performance of AMP activity cliffs remains to be further improved, considering that ESM2 with 33 layers only achieves the Spearman correlation coefficient=0.50 for the regression task of the MIC values on the benchmark dataset. Source code and additional resources are available at https://www.healthinformaticslab.org/supp/ or https://github.com/Kewei2023/AMPCliff-generation.