Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising

The detection limit of astronomical imaging observations is limited by several noise sources. Some of that noise is correlated between neighbouring image pixels and exposures, so in principle could be learned and corrected. We present an astronomical self-supervised transformer-based denoising algorithm (ASTERIS), that integrates spatiotemporal information across multiple exposures. Benchmarking on mock data indicates that ASTERIS improves detection limits by 1.0 magnitude at 90% completeness and purity, while preserving the point spread function and photometric accuracy. Observational validation using data from the James Webb Space Telescope (JWST) and Subaru telescope identifies previously undetectable features, including low-surface-brightness galaxy structures and gravitationally-lensed arcs. Applied to deep JWST images, ASTERIS identifies three times more redshift > 9 galaxy candidates, with rest-frame ultraviolet luminosity 1.0 magnitude fainter, than previous methods.

DriveAction: A Benchmark for Exploring Human-like Driving Decisions in VLA Models

Vision-Language-Action (VLA) models have advanced autonomous driving, but existing benchmarks still lack scenario diversity, reliable action-level annotation, and evaluation protocols aligned with human preferences. To address these limitations, we introduce DriveAction, the first action-driven benchmark specifically designed for VLA models, comprising 16,185 QA pairs generated from 2,610 driving scenarios. DriveAction leverages real-world driving data proactively collected by users of production-level autonomous vehicles to ensure broad and representative scenario coverage, offers high-level discrete action labels collected directly from users' actual driving operations, and implements an action-rooted tree-structured evaluation framework that explicitly links vision, language, and action tasks, supporting both comprehensive and task-specific assessment. Our experiments demonstrate that state-of-the-art vision-language models (VLMs) require both vision and language guidance for accurate action prediction: on average, accuracy drops by 3.3% without vision input, by 4.1% without language input, and by 8.0% without either. Our evaluation supports precise identification of model bottlenecks with robust and consistent results, thus providing new insights and a rigorous foundation for advancing human-like decisions in autonomous driving.

Active learning for efficient discovery of optimal gene combinations in the combinatorial perturbation space

The advancement of novel combinatorial CRISPR screening technologies enables the identification of synergistic gene combinations on a large scale. This is crucial for developing novel and effective combination therapies, but the combinatorial space makes exhaustive experimentation infeasible. We introduce NAIAD, an active learning framework that efficiently discovers optimal gene pairs capable of driving cells toward desired cellular phenotypes. NAIAD leverages single-gene perturbation effects and adaptive gene embeddings that scale with the training data size, mitigating overfitting in small-sample learning while capturing complex gene interactions as more data is collected. Evaluated on four CRISPR combinatorial perturbation datasets totaling over 350,000 genetic interactions, NAIAD, trained on small datasets, outperforms existing models by up to 40\% relative to the second-best. NAIAD's recommendation system prioritizes gene pairs with the maximum predicted effects, resulting in the highest marginal gain in each AI-experiment round and accelerating discovery with fewer CRISPR experimental iterations. Our NAIAD framework (https://github.com/NeptuneBio/NAIAD) improves the identification of novel, effective gene combinations, enabling more efficient CRISPR library design and offering promising applications in genomics research and therapeutic development.