scAgent: Universal Single-Cell Annotation via a LLM Agent

Cell type annotation is critical for understanding cellular heterogeneity. Based on single-cell RNA-seq data and deep learning models, good progress has been made in annotating a fixed number of cell types within a specific tissue. However, universal cell annotation, which can generalize across tissues, discover novel cell types, and extend to novel cell types, remains less explored. To fill this gap, this paper proposes scAgent, a universal cell annotation framework based on Large Language Models (LLMs). scAgent can identify cell types and discover novel cell types in diverse tissues; furthermore, it is data efficient to learn novel cell types. Experimental studies in 160 cell types and 35 tissues demonstrate the superior performance of scAgent in general cell-type annotation, novel cell discovery, and extensibility to novel cell type.

FinSQL: Model-Agnostic LLMs-based Text-to-SQL Framework for Financial Analysis

Text-to-SQL, which provides zero-code interface for operating relational databases, has gained much attention in financial analysis; because, financial professionals may not well-skilled in SQL programming. However, until now, there is no practical Text-to-SQL benchmark dataset for financial analysis, and existing Text-to-SQL methods have not considered the unique characteristics of databases in financial applications, such as commonly existing wide tables. To address these issues, we collect a practical Text-to-SQL benchmark dataset and propose a model-agnostic Large Language Model (LLMs)-based Text-to-SQL framework for financial analysis. The benchmark dataset, BULL, is collected from the practical financial analysis business of Hundsun Technologies Inc., including databases for fund, stock, and macro economy. Besides, the proposed LLMs-based Text-to-SQL framework, FinSQL, provides a systematic treatment for financial Text-to-SQL from the perspectives of prompt construction, parameter-efficient fine-tuning and output calibration. Extensive experimental results on BULL demonstrate that FinSQL achieves the state-of-the-art Text-to-SQL performance at a small cost; furthermore, FinSQL can bring up to 36.64% performance improvement in scenarios requiring few-shot cross-database model transfer.