scAgent: Universal Single-Cell Annotation via a LLM Agent

Cell type annotation is critical for understanding cellular heterogeneity. Based on single-cell RNA-seq data and deep learning models, good progress has been made in annotating a fixed number of cell types within a specific tissue. However, universal cell annotation, which can generalize across tissues, discover novel cell types, and extend to novel cell types, remains less explored. To fill this gap, this paper proposes scAgent, a universal cell annotation framework based on Large Language Models (LLMs). scAgent can identify cell types and discover novel cell types in diverse tissues; furthermore, it is data efficient to learn novel cell types. Experimental studies in 160 cell types and 35 tissues demonstrate the superior performance of scAgent in general cell-type annotation, novel cell discovery, and extensibility to novel cell type.

Distributed Speech Dereverberation Using Weighted Prediction Error

Speech dereverberation aims to alleviate the negative impact of late reverberant reflections. The weighted prediction error (WPE) method is a well-established technique known for its superior performance in dereverberation. However, in scenarios where microphone nodes are dispersed, the centralized approach of the WPE method requires aggregating all observations for inverse filtering, resulting in a significant computational burden. This paper introduces a distributed speech dereverberation method that emphasizes low computational complexity at each node. Specifically, we leverage the distributed adaptive node-specific signal estimation (DANSE) algorithm within the multichannel linear prediction (MCLP) process. This approach empowers each node to perform local operations with reduced complexity while achieving the global performance through inter-node cooperation. Experimental results validate the effectiveness of our proposed method, showcasing its ability to achieve efficient speech dereverberation in dispersed microphone node scenarios.

Distributed pressure matching strategy using diffusion adaptation

Personal sound zone (PSZ) systems, which aim to create listening (bright) and silent (dark) zones in neighboring regions of space, are often based on time-varying acoustics. Conventional adaptive-based methods for handling PSZ tasks suffer from the collection and processing of acoustic transfer functions~(ATFs) between all the matching microphones and all the loudspeakers in a centralized manner, resulting in high calculation complexity and costly accuracy requirements. This paper presents a distributed pressure-matching (PM) method relying on diffusion adaptation (DPM-D) to spread the computational load amongst nodes in order to overcome these issues. The global PM problem is defined as a sum of local costs, and the diffusion adaption approach is then used to create a distributed solution that just needs local information exchanges. Simulations over multi-frequency bins and a computational complexity analysis are conducted to evaluate the properties of the algorithm and to compare it with centralized counterparts.