MedTransformer: Accurate AD Diagnosis for 3D MRI Images through 2D Vision Transformers

Automated diagnosis of AD in brain images is becoming a clinically important technique to support precision and efficient diagnosis and treatment planning. A few efforts have been made to automatically diagnose AD in magnetic resonance imaging (MRI) using three-dimensional CNNs. However, due to the complexity of 3D models, the performance is still unsatisfactory, both in terms of accuracy and efficiency. To overcome the complexities of 3D images and 3D models, in this study, we aim to attack this problem with 2D vision Transformers. We propose a 2D transformer-based medical image model with various transformer attention encoders to diagnose AD in 3D MRI images, by cutting the 3D images into multiple 2D slices.The model consists of four main components: shared encoders across three dimensions, dimension-specific encoders, attention across images from the same dimension, and attention across three dimensions. It is used to obtain attention relationships among multiple sequences from different dimensions (axial, coronal, and sagittal) and multiple slices. We also propose morphology augmentation, an erosion and dilation based method to increase the structural difference between AD and normal images. In this experiment, we use multiple datasets from ADNI, AIBL, MIRAID, OASIS to show the performance of our model. Our proposed MedTransformer demonstrates a strong ability in diagnosing AD. These results demonstrate the effectiveness of MedTransformer in learning from 3D data using a much smaller model and its capability to generalize among different medical tasks, which provides a possibility to help doctors diagnose AD in a simpler way.

On the Communication Complexity of Decentralized Bilevel Optimization

Decentralized bilevel optimization has been actively studied in the past few years since it has widespread applications in machine learning. However, existing algorithms suffer from large communication complexity caused by the estimation of stochastic hypergradient, limiting their application to real-world tasks. To address this issue, we develop a novel decentralized stochastic bilevel gradient descent algorithm under the heterogeneous setting, which enjoys a small communication cost in each round and small communication rounds. As such, it can achieve a much better communication complexity than existing algorithms. Moreover, we extend our algorithm to the more challenging decentralized multi-level optimization. To the best of our knowledge, this is the first time achieving these theoretical results under the heterogeneous setting. At last, the experimental results confirm the efficacy of our algorithm.

Spectral Estimators for Structured Generalized Linear Models via Approximate Message Passing

We consider the problem of parameter estimation from observations given by a generalized linear model. Spectral methods are a simple yet effective approach for estimation: they estimate the parameter via the principal eigenvector of a matrix obtained by suitably preprocessing the observations. Despite their wide use, a rigorous performance characterization of spectral estimators, as well as a principled way to preprocess the data, is available only for unstructured (i.e., i.i.d. Gaussian and Haar) designs. In contrast, real-world design matrices are highly structured and exhibit non-trivial correlations. To address this problem, we consider correlated Gaussian designs which capture the anisotropic nature of the measurements via a feature covariance matrix $\Sigma$. Our main result is a precise asymptotic characterization of the performance of spectral estimators in this setting. This then allows to identify the optimal preprocessing that minimizes the number of samples needed to meaningfully estimate the parameter. Remarkably, such an optimal spectral estimator depends on $\Sigma$ only through its normalized trace, which can be consistently estimated from the data. Numerical results demonstrate the advantage of our principled approach over previous heuristic methods. Existing analyses of spectral estimators crucially rely on the rotational invariance of the design matrix. This key assumption does not hold for correlated Gaussian designs. To circumvent this difficulty, we develop a novel strategy based on designing and analyzing an approximate message passing algorithm whose fixed point coincides with the desired spectral estimator. Our methodology is general, and opens the way to the precise characterization of spiked matrices and of the corresponding spectral methods in a variety of settings.

Can ChatGPT Pass An Introductory Level Functional Language Programming Course?

The recent introduction of ChatGPT has drawn significant attention from both industry and academia due to its impressive capabilities in solving a diverse range of tasks, including language translation, text summarization, and computer programming. Its capability for writing, modifying, and even correcting code together with its ease of use and access is already dramatically impacting computer science education. This paper aims to explore how well ChatGPT can perform in an introductory-level functional language programming course. In our systematic evaluation, we treated ChatGPT as one of our students and demonstrated that it can achieve a grade B- and its rank in the class is 155 out of 314 students overall. Our comprehensive evaluation provides valuable insights into ChatGPT's impact from both student and instructor perspectives. Additionally, we identify several potential benefits that ChatGPT can offer to both groups. Overall, we believe that this study significantly clarifies and advances our understanding of ChatGPT's capabilities and potential impact on computer science education.

Can Decentralized Stochastic Minimax Optimization Algorithms Converge Linearly for Finite-Sum Nonconvex-Nonconcave Problems?

Decentralized minimax optimization has been actively studied in the past few years due to its application in a wide range of machine learning models. However, the current theoretical understanding of its convergence rate is far from satisfactory since existing works only focus on the nonconvex-strongly-concave problem. This motivates us to study decentralized minimax optimization algorithms for the nonconvex-nonconcave problem. To this end, we develop two novel decentralized stochastic variance-reduced gradient descent ascent algorithms for the finite-sum nonconvex-nonconcave problem that satisfies the Polyak-{\L}ojasiewicz (PL) condition. In particular, our theoretical analyses demonstrate how to conduct local updates and perform communication to achieve the linear convergence rate. To the best of our knowledge, this is the first work achieving linear convergence rates for decentralized nonconvex-nonconcave problems. Finally, we verify the performance of our algorithms on both synthetic and real-world datasets. The experimental results confirm the efficacy of our algorithms.

Federated Compositional Deep AUC Maximization

Federated learning has attracted increasing attention due to the promise of balancing privacy and large-scale learning; numerous approaches have been proposed. However, most existing approaches focus on problems with balanced data, and prediction performance is far from satisfactory for many real-world applications where the number of samples in different classes is highly imbalanced. To address this challenging problem, we developed a novel federated learning method for imbalanced data by directly optimizing the area under curve (AUC) score. In particular, we formulate the AUC maximization problem as a federated compositional minimax optimization problem, develop a local stochastic compositional gradient descent ascent with momentum algorithm, and provide bounds on the computational and communication complexities of our algorithm. To the best of our knowledge, this is the first work to achieve such favorable theoretical results. Finally, extensive experimental results confirm the efficacy of our method.

Precise Asymptotics for Spectral Methods in Mixed Generalized Linear Models

In a mixed generalized linear model, the objective is to learn multiple signals from unlabeled observations: each sample comes from exactly one signal, but it is not known which one. We consider the prototypical problem of estimating two statistically independent signals in a mixed generalized linear model with Gaussian covariates. Spectral methods are a popular class of estimators which output the top two eigenvectors of a suitable data-dependent matrix. However, despite the wide applicability, their design is still obtained via heuristic considerations, and the number of samples $n$ needed to guarantee recovery is super-linear in the signal dimension $d$. In this paper, we develop exact asymptotics on spectral methods in the challenging proportional regime in which $n, d$ grow large and their ratio converges to a finite constant. By doing so, we are able to optimize the design of the spectral method, and combine it with a simple linear estimator, in order to minimize the estimation error. Our characterization exploits a mix of tools from random matrices, free probability and the theory of approximate message passing algorithms. Numerical simulations for mixed linear regression and phase retrieval display the advantage enabled by our analysis over existing designs of spectral methods.

Environment Sensing Considering the Occlusion Effect: A Multi-View Approach

In this paper, we consider the problem of sensing the environment within a wireless cellular framework. Specifically, multiple user equipments (UEs) send sounding signals to one or multiple base stations (BSs) and then a centralized processor retrieves the environmental information from all the channel information obtained at the BS(s). Taking into account the occlusion effect that is common in the wireless context, we make full use of the different views of the environment from different users and/or BS(s), and propose an effective sensing algorithm called GAMP-MVSVR (generalized-approximate-message-passing-based multi-view sparse vector reconstruction). In the proposed algorithm, a multi-layer factor graph is constructed to iteratively estimate the scattering coefficients of the cloud points and their occlusion relationship. In each iteration, the occlusion relationship between the cloud points of the sparse environment is recalculated according to a simple occlusion detection rule, and in turn, used to estimate the scattering coefficients of the cloud points. Our proposed algorithm can achieve improved sensing performance with multi-BS collaboration in addition to the multi-views from the UEs. The simulation results verify its convergence and effectiveness.

Mean Estimation in High-Dimensional Binary Markov Gaussian Mixture Models

We consider a high-dimensional mean estimation problem over a binary hidden Markov model, which illuminates the interplay between memory in data, sample size, dimension, and signal strength in statistical inference. In this model, an estimator observes $n$ samples of a $d$-dimensional parameter vector $\theta_{*}\in\mathbb{R}^{d}$, multiplied by a random sign $ S_i $ ($1\le i\le n$), and corrupted by isotropic standard Gaussian noise. The sequence of signs $\{S_{i}\}_{i\in[n]}\in\{-1,1\}^{n}$ is drawn from a stationary homogeneous Markov chain with flip probability $\delta\in[0,1/2]$. As $\delta$ varies, this model smoothly interpolates two well-studied models: the Gaussian Location Model for which $\delta=0$ and the Gaussian Mixture Model for which $\delta=1/2$. Assuming that the estimator knows $\delta$, we establish a nearly minimax optimal (up to logarithmic factors) estimation error rate, as a function of $\|\theta_{*}\|,\delta,d,n$. We then provide an upper bound to the case of estimating $\delta$, assuming a (possibly inaccurate) knowledge of $\theta_{*}$. The bound is proved to be tight when $\theta_{*}$ is an accurately known constant. These results are then combined to an algorithm which estimates $\theta_{*}$ with $\delta$ unknown a priori, and theoretical guarantees on its error are stated.