Heterogeneous network drug-target interaction prediction model based on graph wavelet transform and multi-level contrastive learning

Drug-target interaction (DTI) prediction is a core task in drug development and precision medicine in the biomedical field. However, traditional machine learning methods generally have the black box problem, which makes it difficult to reveal the deep correlation between the model decision mechanism and the interaction pattern between biological molecules. This study proposes a heterogeneous network drug target interaction prediction framework, integrating graph neural network and multi scale signal processing technology to construct a model with both efficient prediction and multi level interpretability. Its technical breakthroughs are mainly reflected in the following three dimensions:Local global feature collaborative perception module. Based on heterogeneous graph convolutional neural network (HGCN), a multi order neighbor aggregation strategy is designed.Multi scale graph signal decomposition and biological interpretation module. A deep hierarchical node feature transform (GWT) architecture is proposed.Contrastive learning combining multi dimensional perspectives and hierarchical representations. By comparing the learning models, the node representations from the two perspectives of HGCN and GWT are aligned and fused, so that the model can integrate multi dimensional information and improve the prediction robustness. Experimental results show that our framework shows excellent prediction performance on all datasets. This study provides a complete solution for drug target discovery from black box prediction to mechanism decoding, and its methodology has important reference value for modeling complex biomolecular interaction systems.

The Spike Gating Flow: A Hierarchical Structure Based Spiking Neural Network for Online Gesture Recognition

Action recognition is an exciting research avenue for artificial intelligence since it may be a game changer in the emerging industrial fields such as robotic visions and automobiles. However, current deep learning faces major challenges for such applications because of the huge computational cost and the inefficient learning. Hence, we develop a novel brain-inspired Spiking Neural Network (SNN) based system titled Spiking Gating Flow (SGF) for online action learning. The developed system consists of multiple SGF units which assembled in a hierarchical manner. A single SGF unit involves three layers: a feature extraction layer, an event-driven layer and a histogram-based training layer. To demonstrate the developed system capabilities, we employ a standard Dynamic Vision Sensor (DVS) gesture classification as a benchmark. The results indicate that we can achieve 87.5% accuracy which is comparable with Deep Learning (DL), but at smaller training/inference data number ratio 1.5:1. And only a single training epoch is required during the learning process. Meanwhile, to the best of our knowledge, this is the highest accuracy among the non-backpropagation algorithm based SNNs. At last, we conclude the few-shot learning paradigm of the developed network: 1) a hierarchical structure-based network design involves human prior knowledge; 2) SNNs for content based global dynamic feature detection.