PA2D-MORL: Pareto Ascent Directional Decomposition based Multi-Objective Reinforcement Learning

Multi-objective reinforcement learning (MORL) provides an effective solution for decision-making problems involving conflicting objectives. However, achieving high-quality approximations to the Pareto policy set remains challenging, especially in complex tasks with continuous or high-dimensional state-action space. In this paper, we propose the Pareto Ascent Directional Decomposition based Multi-Objective Reinforcement Learning (PA2D-MORL) method, which constructs an efficient scheme for multi-objective problem decomposition and policy improvement, leading to a superior approximation of Pareto policy set. The proposed method leverages Pareto ascent direction to select the scalarization weights and computes the multi-objective policy gradient, which determines the policy optimization direction and ensures joint improvement on all objectives. Meanwhile, multiple policies are selectively optimized under an evolutionary framework to approximate the Pareto frontier from different directions. Additionally, a Pareto adaptive fine-tuning approach is applied to enhance the density and spread of the Pareto frontier approximation. Experiments on various multi-objective robot control tasks show that the proposed method clearly outperforms the current state-of-the-art algorithm in terms of both quality and stability of the outcomes.

MO-MIX: Multi-Objective Multi-Agent Cooperative Decision-Making With Deep Reinforcement Learning

Deep reinforcement learning (RL) has been applied extensively to solve complex decision-making problems. In many real-world scenarios, tasks often have several conflicting objectives and may require multiple agents to cooperate, which are the multi-objective multi-agent decision-making problems. However, only few works have been conducted on this intersection. Existing approaches are limited to separate fields and can only handle multi-agent decision-making with a single objective, or multi-objective decision-making with a single agent. In this paper, we propose MO-MIX to solve the multi-objective multi-agent reinforcement learning (MOMARL) problem. Our approach is based on the centralized training with decentralized execution (CTDE) framework. A weight vector representing preference over the objectives is fed into the decentralized agent network as a condition for local action-value function estimation, while a mixing network with parallel architecture is used to estimate the joint action-value function. In addition, an exploration guide approach is applied to improve the uniformity of the final non-dominated solutions. Experiments demonstrate that the proposed method can effectively solve the multi-objective multi-agent cooperative decision-making problem and generate an approximation of the Pareto set. Our approach not only significantly outperforms the baseline method in all four kinds of evaluation metrics, but also requires less computational cost.

RIDER: 3D RNA Inverse Design with Reinforcement Learning-Guided Diffusion

The inverse design of RNA three-dimensional (3D) structures is crucial for engineering functional RNAs in synthetic biology and therapeutics. While recent deep learning approaches have advanced this field, they are typically optimized and evaluated using native sequence recovery, which is a limited surrogate for structural fidelity, since different sequences can fold into similar 3D structures and high recovery does not necessarily indicate correct folding. To address this limitation, we propose RIDER, an RNA Inverse DEsign framework with Reinforcement learning that directly optimizes for 3D structural similarity. First, we develop and pre-train a GNN-based generative diffusion model conditioned on the target 3D structure, achieving a 9% improvement in native sequence recovery over state-of-the-art methods. Then, we fine-tune the model with an improved policy gradient algorithm using four task-specific reward functions based on 3D self-consistency metrics. Experimental results show that RIDER improves structural similarity by over 100% across all metrics and discovers designs that are distinct from native sequences.

Beyond Monotonicity: Revisiting Factorization Principles in Multi-Agent Q-Learning

Value decomposition is a central approach in multi-agent reinforcement learning (MARL), enabling centralized training with decentralized execution by factorizing the global value function into local values. To ensure individual-global-max (IGM) consistency, existing methods either enforce monotonicity constraints, which limit expressive power, or adopt softer surrogates at the cost of algorithmic complexity. In this work, we present a dynamical systems analysis of non-monotonic value decomposition, modeling learning dynamics as continuous-time gradient flow. We prove that, under approximately greedy exploration, all zero-loss equilibria violating IGM consistency are unstable saddle points, while only IGM-consistent solutions are stable attractors of the learning dynamics. Extensive experiments on both synthetic matrix games and challenging MARL benchmarks demonstrate that unconstrained, non-monotonic factorization reliably recovers IGM-optimal solutions and consistently outperforms monotonic baselines. Additionally, we investigate the influence of temporal-difference targets and exploration strategies, providing actionable insights for the design of future value-based MARL algorithms.