GenFAR: A generalized representation of brain structure, derived from 49,246 multi-cohort MRIs via deep learning

Deep learning models for neuroimaging have largely been developed for individual tasks, limiting knowledge transfer across applications. Here we introduce GenFAR, a modular deep learning framework that learns general, clinically informed features from brain MRIs. We trained this modular architecture on 49,246 individuals across 11 cohorts, using 17 diverse classification and regression tasks spanning cognition, clinical, diagnosis, demographics, and biomarkers. This yields aggregated, focused feature sets that capture rich, clinically- and biologically-relevant brain representations. We developed a sequential learning approach where tasks progressively build on previously learned representations. Through an analysis of 5,000 task sequences, we identified an optimal sequence length of six tasks and introduced a Donor Score metric to quantify each task's contribution to downstream performance. This analysis revealed five consistently strong donor tasks (Age, AD/MCI, MMSE, Hypertension, Hyperlipidemia) that formed the base of our sequential model. We demonstrated the utility of our learned representation, in various tasks beyond those included in the training set, to serve as the foundation for specialized secondary predictors. We further showed that using the learned feature representation can substantially increase the sample efficiency of secondary deep learning training tasks and models, as well as improve their accuracy.

Deep Learning Based Detection of Enlarged Perivascular Spaces on Brain MRI

Deep learning has been demonstrated effective in many neuroimaging applications. However, in many scenarios the number of imaging sequences capturing information related to small vessel disease lesions is insufficient to support data-driven techniques. Additionally, cohort-based studies may not always have the optimal or essential imaging sequences for accurate lesion detection. Therefore, it is necessary to determine which of these imaging sequences are essential for accurate detection. In this study we aimed to find the optimal combination of magnetic resonance imaging (MRI) sequences for deep learning-based detection of enlarged perivascular spaces (ePVS). To this end, we implemented an effective light-weight U-Net adapted for ePVS detection and comprehensively investigated different combinations of information from susceptibility weighted imaging (SWI), fluid-attenuated inversion recovery (FLAIR), T1-weighted (T1w) and T2-weighted (T2w) MRI sequences. We conclude that T2w MRI is the most important for accurate ePVS detection, and the incorporation of SWI, FLAIR and T1w MRI in the deep neural network could make insignificant improvements in accuracy.

DEEPMIR: A DEEP convolutional neural network for differential detection of cerebral Microbleeds and IRon deposits in MRI

Background: Cerebral microbleeds (CMBs) and non-hemorrhage iron deposits in the basal ganglia have been associated with brain aging, vascular disease and neurodegenerative disorders. Recent advances using quantitative susceptibility mapping (QSM) make it possible to differentiate iron content from mineralization in-vivo using magnetic resonance imaging (MRI). However, automated detection of such lesions is still challenging, making quantification in large cohort bases studies rather limited. Purpose: Development of a fully automated method using deep learning for detecting CMBs and basal ganglia iron deposits using multimodal MRI. Materials and Methods: We included a convenience sample of 24 participants from the MESA cohort and used T2-weighted images, susceptibility weighted imaging (SWI), and QSM to segment the lesions. We developed a protocol for simultaneous manual annotation of CMBs and non-hemorrhage iron deposits in the basal ganglia, which resulted in defining the gold standard. This gold standard was then used to train a deep convolution neural network (CNN) model. Specifically, we adapted the U-Net model with a higher number of resolution layers to be able to detect small lesions such as CMBs from standard resolution MRI which are used in cohort-based studies. The detection performance was then evaluated using the cross-validation principle in order to ensure generalization of the results. Results: With multi-class CNN models, we achieved an average sensitivity and precision of about 0.8 and 0.6, respectively for detecting CMBs. The same framework detected non-hemorrhage iron deposits reaching an average sensitivity and precision of about 0.8. Conclusions: Our results showed that deep learning could automate the detection of small vessel disease lesions and including multimodal MR data such as QSM can improve the detection of CMB and non-hemorrhage iron deposits.