PlanTwin: Privacy-Preserving Planning Abstractions for Cloud-Assisted LLM Agents

Cloud-hosted large language models (LLMs) have become the de facto planners in agentic systems, coordinating tools and guiding execution over local environments. In many deployments, however, the environment being planned over is private, containing source code, files, credentials, and metadata that cannot be exposed to the cloud. Existing solutions address adjacent concerns, such as execution isolation, access control, or confidential inference, but they do not control what cloud planners observe during planning: within the permitted scope, \textit{raw environment state is still exposed}. We introduce PlanTwin, a privacy-preserving architecture for cloud-assisted planning without exposing raw local context. The key idea is to project the real environment into a \textit{planning-oriented digital twin}: a schema-constrained and de-identified abstract graph that preserves planning-relevant structure while removing reconstructable details. The cloud planner operates solely on this sanitized twin through a bounded capability interface, while a local gatekeeper enforces safety policies and cumulative disclosure budgets. We further formalize the privacy-utility trade-off as a capability granularity problem, define architectural privacy goals using $(k,δ)$-anonymity and $ε$-unlinkability, and mitigate compositional leakage through multi-turn disclosure control. We implement PlanTwin as middleware between local agents and cloud planners and evaluate it on 60 agentic tasks across ten domains with four cloud planners. PlanTwin achieves full sensitive-item non-disclosure (SND = 1.0) while maintaining planning quality close to full-context systems: three of four planners achieve PQS $> 0.79$, and the full pipeline incurs less than 2.2\% utility loss.

NRTR: Neuron Reconstruction with Transformer from 3D Optical Microscopy Images

The neuron reconstruction from raw Optical Microscopy (OM) image stacks is the basis of neuroscience. Manual annotation and semi-automatic neuron tracing algorithms are time-consuming and inefficient. Existing deep learning neuron reconstruction methods, although demonstrating exemplary performance, greatly demand complex rule-based components. Therefore, a crucial challenge is designing an end-to-end neuron reconstruction method that makes the overall framework simpler and model training easier. We propose a Neuron Reconstruction Transformer (NRTR) that, discarding the complex rule-based components, views neuron reconstruction as a direct set-prediction problem. To the best of our knowledge, NRTR is the first image-to-set deep learning model for end-to-end neuron reconstruction. In experiments using the BigNeuron and VISoR-40 datasets, NRTR achieves excellent neuron reconstruction results for comprehensive benchmarks and outperforms competitive baselines. Results of extensive experiments indicate that NRTR is effective at showing that neuron reconstruction is viewed as a set-prediction problem, which makes end-to-end model training available.