Accurate 2D soft segmentation of medical image via SoftGAN network

Accurate 2D lung nodules segmentation from medical Computed Tomography (CT) images is crucial in medical applications. Most current approaches cannot achieve precise segmentation results that preserving both rich edge details description and smooth transition representations between image regions due to the tininess, complexities, and irregularities of lung nodule shapes. To address this issue, we propose a novel Cascaded Generative Adversarial Network (CasGAN) to cope with CT images super-resolution and segmentation tasks, in which the semantic soft segmentation form on precise lesion representation is introduced for the first time according to our knowledge, and lesion edges can be retained accurately after our segmentation that can promote rapid acquisition of high-quality large-scale annotation data based on RECIST weak supervision information. Extensive experiments validate that our CasGAN outperforms the state-of-the-art methods greatly in segmentation quality, which is also robust on the application of medical images beyond lung nodules. Besides, we provide a challenging lung nodules soft segmentation dataset of medical CT images for further studies.