A Position Statement on Endovascular Models and Effectiveness Metrics for Mechanical Thrombectomy Navigation, on behalf of the Stakeholder Taskforce for AI-assisted Robotic Thrombectomy (START)

While we are making progress in overcoming infectious diseases and cancer; one of the major medical challenges of the mid-21st century will be the rising prevalence of stroke. Large vessels occlusions are especially debilitating, yet effective treatment (needed within hours to achieve best outcomes) remains limited due to geography. One solution for improving timely access to mechanical thrombectomy in geographically diverse populations is the deployment of robotic surgical systems. Artificial intelligence (AI) assistance may enable the upskilling of operators in this emerging therapeutic delivery approach. Our aim was to establish consensus frameworks for developing and validating AI-assisted robots for thrombectomy. Objectives included standardizing effectiveness metrics and defining reference testbeds across in silico, in vitro, ex vivo, and in vivo environments. To achieve this, we convened experts in neurointervention, robotics, data science, health economics, policy, statistics, and patient advocacy. Consensus was built through an incubator day, a Delphi process, and a final Position Statement. We identified that the four essential testbed environments each had distinct validation roles. Realism requirements vary: simpler testbeds should include realistic vessel anatomy compatible with guidewire and catheter use, while standard testbeds should incorporate deformable vessels. More advanced testbeds should include blood flow, pulsatility, and disease features. There are two macro-classes of effectiveness metrics: one for in silico, in vitro, and ex vivo stages focusing on technical navigation, and another for in vivo stages, focused on clinical outcomes. Patient safety is central to this technology's development. One requisite patient safety task needed now is to correlate in vitro measurements to in vivo complications.

Automatic Tool Landmark Detection for Stereo Vision in Robot-Assisted Retinal Surgery

Computer vision and robotics are being increasingly applied in medical interventions. Especially in interventions where extreme precision is required they could make a difference. One such application is robot-assisted retinal microsurgery. In recent works, such interventions are conducted under a stereo-microscope, and with a robot-controlled surgical tool. The complementarity of computer vision and robotics has however not yet been fully exploited. In order to improve the robot control we are interested in 3D reconstruction of the anatomy and in automatic tool localization using a stereo microscope. In this paper, we solve this problem for the first time using a single pipeline, starting from uncalibrated cameras to reach metric 3D reconstruction and registration, in retinal microsurgery. The key ingredients of our method are: (a) surgical tool landmark detection, and (b) 3D reconstruction with the stereo microscope, using the detected landmarks. To address the former, we propose a novel deep learning method that detects and recognizes keypoints in high definition images at higher than real-time speed. We use the detected 2D keypoints along with their corresponding 3D coordinates obtained from the robot sensors to calibrate the stereo microscope using an affine projection model. We design an online 3D reconstruction pipeline that makes use of smoothness constraints and performs robot-to-camera registration. The entire pipeline is extensively validated on open-sky porcine eye sequences. Quantitative and qualitative results are presented for all steps.