T1/T2 relaxation temporal modelling from accelerated acquisitions using a Latent Transformer

Quantitative cardiac magnetic resonance T1 and T2 mapping enable myocardial tissue characterisation but the lengthy scan times restrict their widespread clinical application. We propose a deep learning method that incorporates a time dependency Latent Transformer module to model relationships between parameterised time frames for improved reconstruction from undersampled data. The module, implemented as a multi-resolution sequence-to-sequence transformer, is integrated into an encoder-decoder architecture to leverage the inherent temporal correlations in relaxation processes. The presented results for accelerated T1 and T2 mapping show the model recovers maps with higher fidelity by explicit incorporation of time dynamics. This work demonstrates the importance of temporal modelling for artifact-free reconstruction in quantitative MRI.

Review of data types and model dimensionality for cardiac DTI SMS-related artefact removal

As diffusion tensor imaging (DTI) gains popularity in cardiac imaging due to its unique ability to non-invasively assess the cardiac microstructure, deep learning-based Artificial Intelligence is becoming a crucial tool in mitigating some of its drawbacks, such as the long scan times. As it often happens in fast-paced research environments, a lot of emphasis has been put on showing the capability of deep learning while often not enough time has been spent investigating what input and architectural properties would benefit cardiac DTI acceleration the most. In this work, we compare the effect of several input types (magnitude images vs complex images), multiple dimensionalities (2D vs 3D operations), and multiple input types (single slice vs multi-slice) on the performance of a model trained to remove artefacts caused by a simultaneous multi-slice (SMS) acquisition. Despite our initial intuition, our experiments show that, for a fixed number of parameters, simpler 2D real-valued models outperform their more advanced 3D or complex counterparts. The best performance is although obtained by a real-valued model trained using both the magnitude and phase components of the acquired data. We believe this behaviour to be due to real-valued models making better use of the lower number of parameters, and to 3D models not being able to exploit the spatial information because of the low SMS acceleration factor used in our experiments.

Faster Diffusion Cardiac MRI with Deep Learning-based breath hold reduction

Diffusion Tensor Cardiac Magnetic Resonance (DT-CMR) enables us to probe the microstructural arrangement of cardiomyocytes within the myocardium in vivo and non-invasively, which no other imaging modality allows. This innovative technology could revolutionise the ability to perform cardiac clinical diagnosis, risk stratification, prognosis and therapy follow-up. However, DT-CMR is currently inefficient with over six minutes needed to acquire a single 2D static image. Therefore, DT-CMR is currently confined to research but not used clinically. We propose to reduce the number of repetitions needed to produce DT-CMR datasets and subsequently de-noise them, decreasing the acquisition time by a linear factor while maintaining acceptable image quality. Our proposed approach, based on Generative Adversarial Networks, Vision Transformers, and Ensemble Learning, performs significantly and considerably better than previous proposed approaches, bringing single breath-hold DT-CMR closer to reality.