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Massimo Filippi

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Segmentation of Multiple Sclerosis Lesions across Hospitals: Learn Continually or Train from Scratch?

Oct 27, 2022
Enamundram Naga Karthik, Anne Kerbrat, Pierre Labauge, Tobias Granberg, Jason Talbott, Daniel S. Reich, Massimo Filippi, Rohit Bakshi, Virginie Callot, Sarath Chandar, Julien Cohen-Adad

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Segmentation of Multiple Sclerosis (MS) lesions is a challenging problem. Several deep-learning-based methods have been proposed in recent years. However, most methods tend to be static, that is, a single model trained on a large, specialized dataset, which does not generalize well. Instead, the model should learn across datasets arriving sequentially from different hospitals by building upon the characteristics of lesions in a continual manner. In this regard, we explore experience replay, a well-known continual learning method, in the context of MS lesion segmentation across multi-contrast data from 8 different hospitals. Our experiments show that replay is able to achieve positive backward transfer and reduce catastrophic forgetting compared to sequential fine-tuning. Furthermore, replay outperforms the multi-domain training, thereby emerging as a promising solution for the segmentation of MS lesions. The code is available at this link: https://github.com/naga-karthik/continual-learning-ms

* Accepted at the Medical Imaging Meets NeurIPS (MedNeurIPS) Workshop 2022 
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Multi-branch Convolutional Neural Network for Multiple Sclerosis Lesion Segmentation

Nov 16, 2018
Shahab Aslani, Michael Dayan, Loredana Storelli, Massimo Filippi, Vittorio Murino, Maria A Rocca, Diego Sona

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In this paper, we present an automated approach for segmenting multiple sclerosis (MS) lesions from multi-modal brain magnetic resonance images. Our method is based on a deep end-to-end 2D convolutional neural network (CNN) for slice-based segmentation of 3D volumetric data. The proposed CNN includes a multi-branch downsampling path, which enables the network to encode slices from multiple modalities separately. Multi-scale feature fusion blocks are proposed to combine feature maps from different modalities at different stages of the network. Then, multi-scale feature upsampling blocks are introduced to upsize combined feature maps with different resolutions to leverage information from the lesion shape and location. We trained and tested our model using orthogonal plane orientations of each 3D modality to exploit the contextual information in all directions. The proposed pipeline is evaluated on two different datasets: a private dataset including 37 MS patients and a publicly available dataset known as the ISBI 2015 longitudinal MS lesion segmentation challenge dataset, consisting of 14 MS patients. Considering the ISBI challenge, at the time of submission, our method was amongst the top performing solutions. On the private dataset, using the same array of performance metrics as in the ISBI challenge, the proposed approach shows high improvements in MS lesion segmentation comparing with other publicly available tools.

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Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks

Sep 11, 2018
Charley Gros, Benjamin De Leener, Atef Badji, Josefina Maranzano, Dominique Eden, Sara M. Dupont, Jason Talbott, Ren Zhuoquiong, Yaou Liu, Tobias Granberg, Russell Ouellette, Yasuhiko Tachibana, Masaaki Hori, Kouhei Kamiya, Lydia Chougar, Leszek Stawiarz, Jan Hillert, Elise Bannier, Anne Kerbrat, Gilles Edan, Pierre Labauge, Virginie Callot, Jean Pelletier, Bertrand Audoin, Henitsoa Rasoanandrianina, Jean-Christophe Brisset, Paola Valsasina, Maria A. Rocca, Massimo Filippi, Rohit Bakshi, Shahamat Tauhid, Ferran Prados, Marios Yiannakas, Hugh Kearney, Olga Ciccarelli, Seth Smith, Constantina Andrada Treaba, Caterina Mainero, Jennifer Lefeuvre, Daniel S. Reich, Govind Nair, Vincent Auclair, Donald G. McLaren, Allan R. Martin, Michael G. Fehlings, Shahabeddin Vahdat, Ali Khatibi, Julien Doyon, Timothy Shepherd, Erik Charlson, Sridar Narayanan, Julien Cohen-Adad

Figure 1 for Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks
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Figure 4 for Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks

The spinal cord is frequently affected by atrophy and/or lesions in multiple sclerosis (MS) patients. Segmentation of the spinal cord and lesions from MRI data provides measures of damage, which are key criteria for the diagnosis, prognosis, and longitudinal monitoring in MS. Automating this operation eliminates inter-rater variability and increases the efficiency of large-throughput analysis pipelines. Robust and reliable segmentation across multi-site spinal cord data is challenging because of the large variability related to acquisition parameters and image artifacts. The goal of this study was to develop a fully-automatic framework, robust to variability in both image parameters and clinical condition, for segmentation of the spinal cord and intramedullary MS lesions from conventional MRI data. Scans of 1,042 subjects (459 healthy controls, 471 MS patients, and 112 with other spinal pathologies) were included in this multi-site study (n=30). Data spanned three contrasts (T1-, T2-, and T2*-weighted) for a total of 1,943 volumes. The proposed cord and lesion automatic segmentation approach is based on a sequence of two Convolutional Neural Networks (CNNs). To deal with the very small proportion of spinal cord and/or lesion voxels compared to the rest of the volume, a first CNN with 2D dilated convolutions detects the spinal cord centerline, followed by a second CNN with 3D convolutions that segments the spinal cord and/or lesions. When compared against manual segmentation, our CNN-based approach showed a median Dice of 95% vs. 88% for PropSeg, a state-of-the-art spinal cord segmentation method. Regarding lesion segmentation on MS data, our framework provided a Dice of 60%, a relative volume difference of -15%, and a lesion-wise detection sensitivity and precision of 83% and 77%, respectively. The proposed framework is open-source and readily available in the Spinal Cord Toolbox.

* 38 pages, 7 figures, 2 tables 
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