Investigating the Quality of DermaMNIST and Fitzpatrick17k Dermatological Image Datasets

The remarkable progress of deep learning in dermatological tasks has brought us closer to achieving diagnostic accuracies comparable to those of human experts. However, while large datasets play a crucial role in the development of reliable deep neural network models, the quality of data therein and their correct usage are of paramount importance. Several factors can impact data quality, such as the presence of duplicates, data leakage across train-test partitions, mislabeled images, and the absence of a well-defined test partition. In this paper, we conduct meticulous analyses of two popular dermatological image datasets: DermaMNIST and Fitzpatrick17k, uncovering these data quality issues, measure the effects of these problems on the benchmark results, and propose corrections to the datasets. Besides ensuring the reproducibility of our analysis, by making our analysis pipeline and the accompanying code publicly available, we aim to encourage similar explorations and to facilitate the identification and addressing of potential data quality issues in other large datasets.

DermSynth3D: Synthesis of in-the-wild Annotated Dermatology Images

In recent years, deep learning (DL) has shown great potential in the field of dermatological image analysis. However, existing datasets in this domain have significant limitations, including a small number of image samples, limited disease conditions, insufficient annotations, and non-standardized image acquisitions. To address these shortcomings, we propose a novel framework called DermSynth3D. DermSynth3D blends skin disease patterns onto 3D textured meshes of human subjects using a differentiable renderer and generates 2D images from various camera viewpoints under chosen lighting conditions in diverse background scenes. Our method adheres to top-down rules that constrain the blending and rendering process to create 2D images with skin conditions that mimic in-the-wild acquisitions, ensuring more meaningful results. The framework generates photo-realistic 2D dermoscopy images and the corresponding dense annotations for semantic segmentation of the skin, skin conditions, body parts, bounding boxes around lesions, depth maps, and other 3D scene parameters, such as camera position and lighting conditions. DermSynth3D allows for the creation of custom datasets for various dermatology tasks. We demonstrate the effectiveness of data generated using DermSynth3D by training DL models on synthetic data and evaluating them on various dermatology tasks using real 2D dermatological images. We make our code publicly available at https://github.com/sfu-mial/DermSynth3D.

Attribution-based XAI Methods in Computer Vision: A Review

The advancements in deep learning-based methods for visual perception tasks have seen astounding growth in the last decade, with widespread adoption in a plethora of application areas from autonomous driving to clinical decision support systems. Despite their impressive performance, these deep learning-based models remain fairly opaque in their decision-making process, making their deployment in human-critical tasks a risky endeavor. This in turn makes understanding the decisions made by these models crucial for their reliable deployment. Explainable AI (XAI) methods attempt to address this by offering explanations for such black-box deep learning methods. In this paper, we provide a comprehensive survey of attribution-based XAI methods in computer vision and review the existing literature for gradient-based, perturbation-based, and contrastive methods for XAI, and provide insights on the key challenges in developing and evaluating robust XAI methods.

CIRCLe: Color Invariant Representation Learning for Unbiased Classification of Skin Lesions

While deep learning based approaches have demonstrated expert-level performance in dermatological diagnosis tasks, they have also been shown to exhibit biases toward certain demographic attributes, particularly skin types (e.g., light versus dark), a fairness concern that must be addressed. We propose CIRCLe, a skin color invariant deep representation learning method for improving fairness in skin lesion classification. CIRCLe is trained to classify images by utilizing a regularization loss that encourages images with the same diagnosis but different skin types to have similar latent representations. Through extensive evaluation and ablation studies, we demonstrate CIRCLe's superior performance over the state-of-the-art when evaluated on 16k+ images spanning 6 Fitzpatrick skin types and 114 diseases, using classification accuracy, equal opportunity difference (for light versus dark groups), and normalized accuracy range, a new measure we propose to assess fairness on multiple skin type groups.

A Survey on Deep Learning for Skin Lesion Segmentation

Skin cancer is a major public health problem that could benefit from computer-aided diagnosis to reduce the burden of this common disease. Skin lesion segmentation from images is an important step toward achieving this goal. However, the presence of natural and artificial artifacts (e.g., hair and air bubbles), intrinsic factors (e.g., lesion shape and contrast), and variations in image acquisition conditions make skin lesion segmentation a challenging task. Recently, various researchers have explored the applicability of deep learning models to skin lesion segmentation. In this survey, we cross-examine 134 research papers that deal with deep learning based segmentation of skin lesions. We analyze these works along several dimensions, including input data (datasets, preprocessing, and synthetic data generation), model design (architecture, modules, and losses), and evaluation aspects (data annotation requirements and segmentation performance). We discuss these dimensions both from the viewpoint of select seminal works, and from a systematic viewpoint, examining how those choices have influenced current trends, and how their limitations should be addressed. We summarize all examined works in a comprehensive table to facilitate comparisons.

Multi-Sample $ζ$-mixup: Richer, More Realistic Synthetic Samples from a $p$-Series Interpolant

Modern deep learning training procedures rely on model regularization techniques such as data augmentation methods, which generate training samples that increase the diversity of data and richness of label information. A popular recent method, mixup, uses convex combinations of pairs of original samples to generate new samples. However, as we show in our experiments, mixup can produce undesirable synthetic samples, where the data is sampled off the manifold and can contain incorrect labels. We propose $\zeta$-mixup, a generalization of mixup with provably and demonstrably desirable properties that allows convex combinations of $N \geq 2$ samples, leading to more realistic and diverse outputs that incorporate information from $N$ original samples by using a $p$-series interpolant. We show that, compared to mixup, $\zeta$-mixup better preserves the intrinsic dimensionality of the original datasets, which is a desirable property for training generalizable models. Furthermore, we show that our implementation of $\zeta$-mixup is faster than mixup, and extensive evaluation on controlled synthetic and 24 real-world natural and medical image classification datasets shows that $\zeta$-mixup outperforms mixup and traditional data augmentation techniques.

Sleeping Combinatorial Bandits

In this paper, we study an interesting combination of sleeping and combinatorial stochastic bandits. In the mixed model studied here, at each discrete time instant, an arbitrary \emph{availability set} is generated from a fixed set of \emph{base} arms. An algorithm can select a subset of arms from the \emph{availability set} (sleeping bandits) and receive the corresponding reward along with semi-bandit feedback (combinatorial bandits). We adapt the well-known CUCB algorithm in the sleeping combinatorial bandits setting and refer to it as \CSUCB. We prove -- under mild smoothness conditions -- that the \CSUCB\ algorithm achieves an $O(\log (T))$ instance-dependent regret guarantee. We further prove that (i) when the range of the rewards is bounded, the regret guarantee of \CSUCB\ algorithm is $O(\sqrt{T \log (T)})$ and (ii) the instance-independent regret is $O(\sqrt[3]{T^2 \log(T)})$ in a general setting. Our results are quite general and hold under general environments -- such as non-additive reward functions, volatile arm availability, a variable number of base-arms to be pulled -- arising in practical applications. We validate the proven theoretical guarantees through experiments.

Detection and Longitudinal Tracking of Pigmented Skin Lesions in 3D Total-Body Skin Textured Meshes

We present an automated approach to detect and longitudinally track skin lesions on 3D total-body skin surfaces scans. The acquired 3D mesh of the subject is unwrapped to a 2D texture image, where a trained region convolutional neural network (R-CNN) localizes the lesions within the 2D domain. These detected skin lesions are mapped back to the 3D surface of the subject and, for subjects imaged multiple times, the anatomical correspondences among pairs of meshes and the geodesic distances among lesions are leveraged in our longitudinal lesion tracking algorithm. We evaluated the proposed approach using three sources of data. Firstly, we augmented the 3D meshes of human subjects from the public FAUST dataset with a variety of poses, textures, and images of lesions. Secondly, using a handheld structured light 3D scanner, we imaged a mannequin with multiple synthetic skin lesions at selected location and with varying shapes, sizes, and colours. Finally, we used 3DBodyTex, a publicly available dataset composed of 3D scans imaging the colored (textured) skin of 200 human subjects. We manually annotated locations that appeared to the human eye to contain a pigmented skin lesion as well as tracked a subset of lesions occurring on the same subject imaged in different poses. Our results, on test subjects annotated by three human annotators, suggest that the trained R-CNN detects lesions at a similar performance level as the human annotators. Our lesion tracking algorithm achieves an average accuracy of 80% when identifying corresponding pairs of lesions across subjects imaged in different poses. As there currently is no other large-scale publicly available dataset of 3D total-body skin lesions, we publicly release the 10 mannequin meshes and over 25,000 3DBodyTex manual annotations, which we hope will further research on total-body skin lesion analysis.

A Multi-Arm Bandit Approach To Subset Selection Under Constraints

We explore the class of problems where a central planner needs to select a subset of agents, each with different quality and cost. The planner wants to maximize its utility while ensuring that the average quality of the selected agents is above a certain threshold. When the agents' quality is known, we formulate our problem as an integer linear program (ILP) and propose a deterministic algorithm, namely \dpss\ that provides an exact solution to our ILP. We then consider the setting when the qualities of the agents are unknown. We model this as a Multi-Arm Bandit (MAB) problem and propose \newalgo\ to learn the qualities over multiple rounds. We show that after a certain number of rounds, $\tau$, \newalgo\ outputs a subset of agents that satisfy the average quality constraint with a high probability. Next, we provide bounds on $\tau$ and prove that after $\tau$ rounds, the algorithm incurs a regret of $O(\ln T)$, where $T$ is the total number of rounds. We further illustrate the efficacy of \newalgo\ through simulations. To overcome the computational limitations of \dpss, we propose a polynomial-time greedy algorithm, namely \greedy, that provides an approximate solution to our ILP. We also compare the performance of \dpss\ and \greedy\ through experiments.