Build it, Break it, Repeat: Benchmarking and improving LLM-manipulated disinformation detection in social media posts

Detecting machine-generated disinformation on social media is increasingly difficult as large language models (LLMs) make it easier to generate and rewrite misleading content at scale. Static benchmark evaluations, measuring detector performance on fixed held-out datasets, do not capture how detectors behave when posts are deliberately transformed to evade classification. This paper adapts the Build it, Break it, Fix it framework into Build it, Break it, Repeat (BiBiR): iterative sessions designed to stress-test detectors' robustness under iterative adversarial conditions, evaluating whether models remain reliable when disinformation posts are systematically transformed to evade classification. Across five iterations, the findings show that the best adversarial breakers' transformations came from a combination of back-translation and LLM persona-based rewriting, with the best performing technique achieving a 95% label flip rate (LFR), whilst still preserving the meaning of the original posts. The best builders' model was a triplet contrastive model with a dynamic anchor switching (DASS) architecture, which achieved an average accuracy of 72.68%, outperforming the strong baseline (a fine-tuned e5-small-LoRA) by 15 percentage points on the most robust set of breakers' adversarial attacks. The results demonstrate that an iterative framework best exposes detector weaknesses and pushes robustness improvements; however, it may still require semantic preservation analysis to distinguish valid adversarial evasion from transformations that changed the original disinformation claims' meaning.

Curated AI beats frontier LLMs at pharma asset discovery

General-purpose LLMs with web search are increasingly used to scout the competitive landscape of pharmaceutical pipelines. We benchmark Gosset -- an AI platform with a chat interface backed by curated target-, modality-, and indication-level drug-asset annotations -- against four frontier systems with web access (Claude Opus 4.7, GPT 5.5, Gemini 3.1 Pro, Perplexity sonar-pro) on ten niche oncology/immunology targets where most of the pipeline lives in the long tail of preclinical and Asian-developed assets. All five systems receive the same natural-language query and the same JSON output schema. Across 10 targets Gosset returns 3.2x more verified drugs per query than the best frontier system, at perfect precision and 100% recall against the cross-system union of verified drugs. The same curated index is exposed as a Gosset MCP server that any frontier model can call as a tool, suggesting that each of these systems can close most of the recall gap by swapping generic web search for a curated index behind the same chat interface.

Target-Specific Action Classification for Automated Assessment of Human Motor Behavior from Video

Objective monitoring and assessment of human motor behavior can improve the diagnosis and management of several medical conditions. Over the past decade, significant advances have been made in the use of wearable technology for continuously monitoring human motor behavior in free-living conditions. However, wearable technology remains ill-suited for applications which require monitoring and interpretation of complex motor behaviors (e.g. involving interactions with the environment). Recent advances in computer vision and deep learning have opened up new possibilities for extracting information from video recordings. In this paper, we present a hierarchical vision-based behavior phenotyping method for classification of basic human actions in video recordings performed using a single RGB camera. Our method addresses challenges associated with tracking multiple human actors and classification of actions in videos recorded in changing environments with different fields of view. We implement a cascaded pose tracker that uses temporal relationships between detections for short-term tracking and appearance-based tracklet fusion for long-term tracking. Furthermore, for action classification, we use pose evolution maps derived from the cascaded pose tracker as low-dimensional and interpretable representations of the movement sequences for training a convolutional neural network. The cascaded pose tracker achieves an average accuracy of 88\% in tracking the target human actor in our video recordings, and overall system achieves average test accuracy of 84\% for target-specific action classification in untrimmed video recordings.

Predicting Future Opioid Incidences Today

According to the Center of Disease Control (CDC), the Opioid epidemic has claimed more than 72,000 lives in the US in 2017 alone. In spite of various efforts at the local, state and federal level, the impact of the epidemic is becoming progressively worse, as evidenced by the fact that the number of Opioid related deaths increased by 12.5\% between 2016 and 2017. Predictive analytics can play an important role in combating the epidemic by providing decision making tools to stakeholders at multiple levels - from health care professionals to policy makers to first responders. Generating Opioid incidence heat maps from past data, aid these stakeholders to visualize the profound impact of the Opioid epidemic. Such post-fact creation of the heat map provides only retrospective information, and as a result, may not be as useful for preventive action in the current or future time-frames. In this paper, we present a novel deep neural architecture, which learns subtle spatio-temporal variations in Opioid incidences data and accurately predicts future heat maps. We evaluated the efficacy of our model on two open source datasets- (i) The Cincinnati Heroin Overdose dataset, and (ii) Connecticut Drug Related Death Dataset.