The MAMA-MIA Challenge: Advancing Generalizability and Fairness in Breast MRI Tumor Segmentation and Treatment Response Prediction

Breast cancer is the most frequently diagnosed malignancy among women worldwide and a leading cause of cancer-related mortality. Dynamic contrast-enhanced magnetic resonance imaging plays a central role in tumor characterization and treatment monitoring, particularly in patients receiving neoadjuvant chemotherapy. However, existing artificial intelligence models for breast magnetic resonance imaging are often developed using single-center data and evaluated using aggregate performance metrics, limiting their generalizability and obscuring potential performance disparities across demographic subgroups. The MAMA-MIA Challenge was designed to address these limitations by introducing a large-scale benchmark that jointly evaluates primary tumor segmentation and prediction of pathologic complete response using pre-treatment magnetic resonance imaging only. The training cohort comprised 1,506 patients from multiple institutions in the United States, while evaluation was conducted on an external test set of 574 patients from three independent European centers to assess cross-continental and cross-institutional generalization. A unified scoring framework combined predictive performance with subgroup consistency across age, menopausal status, and breast density. Twenty-six international teams participated in the final evaluation phase. Results demonstrate substantial performance variability under external testing and reveal trade-offs between overall accuracy and subgroup fairness. The challenge provides standardized datasets, evaluation protocols, and public resources to promote the development of robust and equitable artificial intelligence systems for breast cancer imaging.

Depth to Anatomy: Learning Internal Organ Locations from Surface Depth Images

Automated patient positioning plays an important role in optimizing scanning procedure and improving patient throughput. Leveraging depth information captured by RGB-D cameras presents a promising approach for estimating internal organ positions, thereby enabling more accurate and efficient positioning. In this work, we propose a learning-based framework that directly predicts the 3D locations and shapes of multiple internal organs from single 2D depth images of the body surface. Utilizing a large-scale dataset of full-body MRI scans, we synthesize depth images paired with corresponding anatomical segmentations to train a unified convolutional neural network architecture. Our method accurately localizes a diverse set of anatomical structures, including bones and soft tissues, without requiring explicit surface reconstruction. Experimental results demonstrate the potential of integrating depth sensors into radiology workflows to streamline scanning procedures and enhance patient experience through automated patient positioning.