M3Net: A Macro-to-Meso-to-Micro Clinical-inspired Hierarchical 3D Network for Pulmonary Nodule Classification

The accurate classification of benign and malignant pulmonary nodules in CT scans is critical for early lung cancer screening, yet remains challenging due to the multi-scale and heterogeneous nature of pulmonary nodules. While deep learning offers potential for auxiliary diagnosis, most existing models act as "black boxes", lacking the transparency and explainability required for trustworthy clinical integration. To address this issue, we propose M3Net, a novel 3D network for pulmonary nodule classification inspired by the hierarchical diagnostic workflow of radiologists, which integrates multi-scale contextual information from fine-grained structures to global anatomical relationships. Our framework constructs a progressive multi-scale input, from fine-grained nodule structures to local semantics and global spatial relationships. M3Net employs scale-specific encoders and ensures cross-scale semantic consistency through latent space projection and mutual information maximization. Extensive experiments on the public LIDC-IDRI dataset and a self-collected clinical dataset (USTC-FHLN) demonstrate that our method achieves state-of-the-art performance, with accuracies of 86.96% and 84.24% respectively, outperforming the best baseline by 3.26% and 2.17%. The results validate that M3Net provides a more robust and clinically relevant solution for pulmonary nodule classification. The code is available at https://github.com/jylEcho/M3-Net.

PathMem: Toward Cognition-Aligned Memory Transformation for Pathology MLLMs

Computational pathology demands both visual pattern recognition and dynamic integration of structured domain knowledge, including taxonomy, grading criteria, and clinical evidence. In practice, diagnostic reasoning requires linking morphological evidence with formal diagnostic and grading criteria. Although multimodal large language models (MLLMs) demonstrate strong vision language reasoning capabilities, they lack explicit mechanisms for structured knowledge integration and interpretable memory control. As a result, existing models struggle to consistently incorporate pathology-specific diagnostic standards during reasoning. Inspired by the hierarchical memory process of human pathologists, we propose PathMem, a memory-centric multimodal framework for pathology MLLMs. PathMem organizes structured pathology knowledge as a long-term memory (LTM) and introduces a Memory Transformer that models the dynamic transition from LTM to working memory (WM) through multimodal memory activation and context-aware knowledge grounding, enabling context-aware memory refinement for downstream reasoning. PathMem achieves SOTA performance across benchmarks, improving WSI-Bench report generation (12.8% WSI-Precision, 10.1% WSI-Relevance) and open-ended diagnosis by 9.7% and 8.9% over prior WSI-based models.

Adversarial Robustness in Unsupervised Machine Learning: A Systematic Review

As the adoption of machine learning models increases, ensuring robust models against adversarial attacks is increasingly important. With unsupervised machine learning gaining more attention, ensuring it is robust against attacks is vital. This paper conducts a systematic literature review on the robustness of unsupervised learning, collecting 86 papers. Our results show that most research focuses on privacy attacks, which have effective defenses; however, many attacks lack effective and general defensive measures. Based on the results, we formulate a model on the properties of an attack on unsupervised learning, contributing to future research by providing a model to use.