Low-Cost and Detunable Wireless Resonator Glasses for Enhanced Eye MRI with Concurrent High-Quality Whole Brain MRI

Purpose: To develop and evaluate a wearable wireless resonator glasses design that enhances eye MRI signal-to-noise ratio (SNR) without compromising whole-brain image quality at 7 T. Methods: The device integrates two detunable LC loop resonators into a lightweight, 3D-printed frame positioned near the eyes. The resonators passively couple to a standard 2Tx/32Rx head coil without hardware modifications. Bench tests assessed tuning, isolation, and detuning performance. B1$^+$ maps were measured in a head/shoulder phantom, and SNR maps were obtained in both phantom and in vivo experiments. Results: Bench measurements confirmed accurate tuning, strong inter-element isolation, and effective passive detuning. Phantom B1$^+$ mapping showed negligible differences between configurations with and without the resonators. Phantom and in vivo imaging demonstrated up to about a 3-fold SNR gain in the eye region, with no measurable SNR loss in the brain. Conclusion: The wireless resonator glasses provide a low-cost, easy-to-use solution that improves ocular SNR while preserving whole-brain image quality, enabling both dedicated eye MRI and simultaneous eye-brain imaging at ultrahigh field.

The Neuron as a Direct Data-Driven Controller

In the quest to model neuronal function amidst gaps in physiological data, a promising strategy is to develop a normative theory that interprets neuronal physiology as optimizing a computational objective. This study extends the current normative models, which primarily optimize prediction, by conceptualizing neurons as optimal feedback controllers. We posit that neurons, especially those beyond early sensory areas, act as controllers, steering their environment towards a specific desired state through their output. This environment comprises both synaptically interlinked neurons and external motor sensory feedback loops, enabling neurons to evaluate the effectiveness of their control via synaptic feedback. Utilizing the novel Direct Data-Driven Control (DD-DC) framework, we model neurons as biologically feasible controllers which implicitly identify loop dynamics, infer latent states and optimize control. Our DD-DC neuron model explains various neurophysiological phenomena: the shift from potentiation to depression in Spike-Timing-Dependent Plasticity (STDP) with its asymmetry, the duration and adaptive nature of feedforward and feedback neuronal filters, the imprecision in spike generation under constant stimulation, and the characteristic operational variability and noise in the brain. Our model presents a significant departure from the traditional, feedforward, instant-response McCulloch-Pitts-Rosenblatt neuron, offering a novel and biologically-informed fundamental unit for constructing neural networks.