A Gaussian Process Regression based Dynamical Models Learning Algorithm for Target Tracking

Maneuvering target tracking is a challenging problem for sensor systems because of the unpredictability of the targets' motions. This paper proposes a novel data-driven method for learning the dynamical motion model of a target. Non-parametric Gaussian process regression (GPR) is used to learn a target's naturally shift invariant motion (NSIM) behavior, which is translationally invariant and does not need to be constantly updated as the target moves. The learned Gaussian processes (GPs) can be applied to track targets within different surveillance regions from the surveillance region of the training data by being incorporated into the particle filter (PF) implementation. The performance of our proposed approach is evaluated over different maneuvering scenarios by being compared with commonly used interacting multiple model (IMM)-PF methods and provides around $90\%$ performance improvement for a multi-target tracking (MTT) highly maneuvering scenario.

Adaptive Kernel Kalman Filter

Sequential Bayesian filters in non-linear dynamic systems require the recursive estimation of the predictive and posterior distributions. This paper introduces a Bayesian filter called the adaptive kernel Kalman filter (AKKF). With this filter, the arbitrary predictive and posterior distributions of hidden states are approximated using the empirical kernel mean embeddings (KMEs) in reproducing kernel Hilbert spaces (RKHSs). In parallel with the KMEs, some particles, in the data space, are used to capture the properties of the dynamical system model. Specifically, particles are generated and updated in the data space, while the corresponding kernel weight mean vector and covariance matrix associated with the feature mappings of the particles are predicted and updated in the RKHSs based on the kernel Kalman rule (KKR). Simulation results are presented to confirm the improved performance of our approach with significantly reduced particle numbers, by comparing with the unscented Kalman filter (UKF), particle filter (PF) and Gaussian particle filter (GPF). For example, compared with the GPF, the proposed approach provides around 5% logarithmic mean square error (LMSE) tracking performance improvement in the bearing-only tracking (BOT) system when using 50 particles.

Deep Learning-Assisted Co-registration of Full-Spectral Autofluorescence Lifetime Microscopic Images with H&E-Stained Histology Images

Autofluorescence lifetime images reveal unique characteristics of endogenous fluorescence in biological samples. Comprehensive understanding and clinical diagnosis rely on co-registration with the gold standard, histology images, which is extremely challenging due to the difference of both images. Here, we show an unsupervised image-to-image translation network that significantly improves the success of the co-registration using a conventional optimisation-based regression network, applicable to autofluorescence lifetime images at different emission wavelengths. A preliminary blind comparison by experienced researchers shows the superiority of our method on co-registration. The results also indicate that the approach is applicable to various image formats, like fluorescence intensity images. With the registration, stitching outcomes illustrate the distinct differences of the spectral lifetime across an unstained tissue, enabling macro-level rapid visual identification of lung cancer and cellular-level characterisation of cell variants and common types. The approach could be effortlessly extended to lifetime images beyond this range and other staining technologies.