Representation Learning for Distributional Perturbation Extrapolation

We consider the problem of modelling the effects of unseen perturbations such as gene knockdowns or drug combinations on low-level measurements such as RNA sequencing data. Specifically, given data collected under some perturbations, we aim to predict the distribution of measurements for new perturbations. To address this challenging extrapolation task, we posit that perturbations act additively in a suitable, unknown embedding space. More precisely, we formulate the generative process underlying the observed data as a latent variable model, in which perturbations amount to mean shifts in latent space and can be combined additively. Unlike previous work, we prove that, given sufficiently diverse training perturbations, the representation and perturbation effects are identifiable up to affine transformation, and use this to characterize the class of unseen perturbations for which we obtain extrapolation guarantees. To estimate the model from data, we propose a new method, the perturbation distribution autoencoder (PDAE), which is trained by maximising the distributional similarity between true and predicted perturbation distributions. The trained model can then be used to predict previously unseen perturbation distributions. Empirical evidence suggests that PDAE compares favourably to existing methods and baselines at predicting the effects of unseen perturbations.

Provident Vehicle Detection at Night: The PVDN Dataset

For advanced driver assistance systems, it is crucial to have information about oncoming vehicles as early as possible. At night, this task is especially difficult due to poor lighting conditions. For that, during nighttime, every vehicle uses headlamps to improve sight and therefore ensure safe driving. As humans, we intuitively assume oncoming vehicles before the vehicles are actually physically visible by detecting light reflections caused by their headlamps. In this paper, we present a novel dataset containing 59746 annotated grayscale images out of 346 different scenes in a rural environment at night. In these images, all oncoming vehicles, their corresponding light objects (e.g., headlamps), and their respective light reflections (e.g., light reflections on guardrails) are labeled. This is accompanied by an in-depth analysis of the dataset characteristics. With that, we are providing the first open-source dataset with comprehensive ground truth data to enable research into new methods of detecting oncoming vehicles based on the light reflections they cause, long before they are directly visible. We consider this as an essential step to further close the performance gap between current advanced driver assistance systems and human behavior.