Active Evidence-Seeking and Diagnostic Reasoning in Large Language Models for Clinical Decision Support

Large language models perform well on static medical examinations, yet clinical diagnosis often requires iterative evidence gathering under uncertainty. Building on prior interactive evaluation efforts, we introduce an OSCE-inspired standardized patient simulator and a controlled, reproducible benchmark for active diagnostic inquiry. Across 468 cases and 15 models in our protocol, we observe that multi-turn evidence seeking reduces diagnostic accuracy by 12.75% and lowers supporting-evidence quality by 24.36% relative to full-context evaluation; error analyses associate these drops with premature diagnostic closure and inefficient questioning. Together, these results suggest that static full-context benchmarks may overestimate performance in interactive evidence-seeking settings, motivating complementary interactive assessment for safer clinical decision support.

From Answers to Arguments: Toward Trustworthy Clinical Diagnostic Reasoning with Toulmin-Guided Curriculum Goal-Conditioned Learning

The integration of Large Language Models (LLMs) into clinical decision support is critically obstructed by their opaque and often unreliable reasoning. In the high-stakes domain of healthcare, correct answers alone are insufficient; clinical practice demands full transparency to ensure patient safety and enable professional accountability. A pervasive and dangerous weakness of current LLMs is their tendency to produce "correct answers through flawed reasoning." This issue is far more than a minor academic flaw; such process errors signal a fundamental lack of robust understanding, making the model prone to broader hallucinations and unpredictable failures when faced with real-world clinical complexity. In this paper, we establish a framework for trustworthy clinical argumentation by adapting the Toulmin model to the diagnostic process. We propose a novel training pipeline: Curriculum Goal-Conditioned Learning (CGCL), designed to progressively train LLM to generate diagnostic arguments that explicitly follow this Toulmin structure. CGCL's progressive three-stage curriculum systematically builds a solid clinical argument: (1) extracting facts and generating differential diagnoses; (2) justifying a core hypothesis while rebutting alternatives; and (3) synthesizing the analysis into a final, qualified conclusion. We validate CGCL using T-Eval, a quantitative framework measuring the integrity of the diagnosis reasoning. Experiments show that our method achieves diagnostic accuracy and reasoning quality comparable to resource-intensive Reinforcement Learning (RL) methods, while offering a more stable and efficient training pipeline.

Curiosity Driven Knowledge Retrieval for Mobile Agents

Mobile agents have made progress toward reliable smartphone automation, yet performance in complex applications remains limited by incomplete knowledge and weak generalization to unseen environments. We introduce a curiosity driven knowledge retrieval framework that formalizes uncertainty during execution as a curiosity score. When this score exceeds a threshold, the system retrieves external information from documentation, code repositories, and historical trajectories. Retrieved content is organized into structured AppCards, which encode functional semantics, parameter conventions, interface mappings, and interaction patterns. During execution, an enhanced agent selectively integrates relevant AppCards into its reasoning process, thereby compensating for knowledge blind spots and improving planning reliability. Evaluation on the AndroidWorld benchmark shows consistent improvements across backbones, with an average gain of six percentage points and a new state of the art success rate of 88.8\% when combined with GPT-5. Analysis indicates that AppCards are particularly effective for multi step and cross application tasks, while improvements depend on the backbone model. Case studies further confirm that AppCards reduce ambiguity, shorten exploration, and support stable execution trajectories. Task trajectories are publicly available at https://lisalsj.github.io/Droidrun-appcard/.