Enhancing Fully Formatted End-to-End Speech Recognition with Knowledge Distillation via Multi-Codebook Vector Quantization

Conventional automatic speech recognition (ASR) models typically produce outputs as normalized texts lacking punctuation and capitalization, necessitating post-processing models to enhance readability. This approach, however, introduces additional complexity and latency due to the cascaded system design. In response to this challenge, there is a growing trend to develop end-to-end (E2E) ASR models capable of directly predicting punctuation and capitalization, though this area remains underexplored. In this paper, we propose an enhanced fully formatted E2E ASR model that leverages knowledge distillation (KD) through multi-codebook vector quantization (MVQ). Experimental results demonstrate that our model significantly outperforms previous works in word error rate (WER) both with and without punctuation and capitalization, and in punctuation error rate (PER). Evaluations on the LibriSpeech-PC test-clean and test-other subsets show that our model achieves state-of-the-art results.

Predicting breast tumor proliferation from whole-slide images: the TUPAC16 challenge

Tumor proliferation is an important biomarker indicative of the prognosis of breast cancer patients. Assessment of tumor proliferation in a clinical setting is highly subjective and labor-intensive task. Previous efforts to automate tumor proliferation assessment by image analysis only focused on mitosis detection in predefined tumor regions. However, in a real-world scenario, automatic mitosis detection should be performed in whole-slide images (WSIs) and an automatic method should be able to produce a tumor proliferation score given a WSI as input. To address this, we organized the TUmor Proliferation Assessment Challenge 2016 (TUPAC16) on prediction of tumor proliferation scores from WSIs. The challenge dataset consisted of 500 training and 321 testing breast cancer histopathology WSIs. In order to ensure fair and independent evaluation, only the ground truth for the training dataset was provided to the challenge participants. The first task of the challenge was to predict mitotic scores, i.e., to reproduce the manual method of assessing tumor proliferation by a pathologist. The second task was to predict the gene expression based PAM50 proliferation scores from the WSI. The best performing automatic method for the first task achieved a quadratic-weighted Cohen's kappa score of $\kappa$ = 0.567, 95% CI [0.464, 0.671] between the predicted scores and the ground truth. For the second task, the predictions of the top method had a Spearman's correlation coefficient of r = 0.617, 95% CI [0.581 0.651] with the ground truth. This was the first study that investigated tumor proliferation assessment from WSIs. The achieved results are promising given the difficulty of the tasks and weakly-labelled nature of the ground truth. However, further research is needed to improve the practical utility of image analysis methods for this task.